Sudden coronary death: The occurrence of platelet aggregates in the epicardial arteries of man

Hærem, Jørgen W.

doi:10.1016/0021-9150(71)90070-0

Cited by 95 publications

(24 citation statements)

References 18 publications

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“…Histologic evidence of platelet thrombi in the coronary arteries ofpatients who suffered sudden death (40), the efficacy of aspirin in unstable angina (41), and our recent demonstration that thromboxane A2 biosynthesis increases coincident with chest pain in patients with unstable angina (42) also implicate thromboxane-dependent platelet activation in human syndromes ofcoronary vascular occlusion. We conclude that thromboxane A2/prostaglandin endoperoxide receptor antagonists promise to be selective probes in further clarifying the role of thromboxane A2 formation in vivo and represent a novel approach to the treatment of vasoocclusive disease in man.…”

Section: Discussionmentioning

confidence: 95%

Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.

Fitzgerald¹,

Doran²,

Jackson³

et al. 1986

J. Clin. Invest.

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The use of enzyme inhibitors to clarify the role of thromboxane A2 in vasoocclusive disease has been complicated by their nonspecific action. To address this problem we have examined the effects of thromboxane A2/prostaglandin endoperoxide receptor antagonism in a canine model of platelet-dependent coronary occlusion. Two structurally distinct thromboxane A2/prostaglandin endoperoxide receptor antagonists, 3-carboxyl-dibenzo and/or endoperoxide formation in vivo.

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Section: Discussionmentioning

confidence: 95%

Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.

Fitzgerald¹,

Doran²,

Jackson³

et al. 1986

J. Clin. Invest.

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“…lets leading to adhesion of platelets to the endothelium-denuded areas and transport of microaggregates downstream of the coronary tree [5]. In porcine coronary arteries with an altered endothelium (regenerated or atherosclerotic), the endothelium facilitates contraction to serotonin via release of an endothelium-derived contracting factor (a cyclooxygenase product) since this is blocked by indomethacin [6].…”

mentioning

confidence: 99%

Effect of Ageing on the Passive and Active Tension and Pharmacodynamic Characteristics of Rat Coronary Arteries: Age-Dependent Increase in Sensitivity to 5-HT and K⁺

Sheykhzade

Simonsen²,

Boonen³

et al. 2012

Pharmacology

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The influence of ageing on the passive and active tension and pharmacodynamic characteristics of intramural coronary arteries from 3-month-old and 2-year-old male Wistar rats was investigated using an isometric myograph. The passive vessel wall tension measured in Ca²⁺-free physiological salt solution at L₀ was significantly greater in arteries from old rats (1.46 ± 0.10 Nm^–1, n = 7) than in young rats (1.13 ± 0.13 Nm^–1, n = 6). However, the maximal active tension at L₀ was similar. The spontaneous myogenic tone was increased by age and the vasorelaxation induced by extracellular K⁺ was significantly higher in coronary arteries of old rats. The sensitivity (pD₂) to 5-HT was significantly higher in arteries from old (6.43 ± 0.11, n = 22) than from young rats (6.16 ± 0.08, n = 29). Ketanserin induced a concentration-dependent rightward shift of the 5-HT concentration-response curve in arteries from both young and old rats. The slopes of the regression lines of the Schild plots were not significantly different from unity and the estimated pK_B values for ketanserin were similar. In conclusion, ageing is associated with changes in passive mechanical characteristics as well as changes in pharmacological properties in rat coronary small arteries.

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“…HAEREM (1971HAEREM ( , 1974 fand haufig in epikardialen Kranzarterien Plattchenthromben, ohne daB sieh aber signifikante Haufigkeitsunterschiede gegentiber Kontrollen fanden. EL-MARAGHI u.…”

Section: Veranderungen In Der Mikrozirkulationunclassified

Durchblutungsstörungen des Myokard

Hort¹,

Arnold²,

Frenzel³

2000

Pathologie Des Endokard, Der Kranzarterien Und Des Myokard

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Sudden coronary death: The occurrence of platelet aggregates in the epicardial arteries of man

Cited by 95 publications

References 18 publications

Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.

Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.

Effect of Ageing on the Passive and Active Tension and Pharmacodynamic Characteristics of Rat Coronary Arteries: Age-Dependent Increase in Sensitivity to 5-HT and K⁺

Durchblutungsstörungen des Myokard

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Sudden coronary death: The occurrence of platelet aggregates in the epicardial arteries of man

Cited by 95 publications

References 18 publications

Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.

Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo.

Effect of Ageing on the Passive and Active Tension and Pharmacodynamic Characteristics of Rat Coronary Arteries: Age-Dependent Increase in Sensitivity to 5-HT and K+

Durchblutungsstörungen des Myokard

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Effect of Ageing on the Passive and Active Tension and Pharmacodynamic Characteristics of Rat Coronary Arteries: Age-Dependent Increase in Sensitivity to 5-HT and K⁺