Sudden cardiac deaths have higher proportion of left stellate ganglionitis

Tse, Rexson; Garland, Jack; McCarthy, Sinead; Ondruschka, Benjamin; Bardsley, Emma N.; Wong, Christopher X.; Stables, Simon; Paton, Julian F. R.

doi:10.1007/s12024-022-00466-5

Cited by 5 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, many drugs have been withdrawn from the market due to sudden cardiac death . In the preclinical study stage, 24% of drugs were discontinued due to cardiovascular side effects, and 45% of drugs were withdrawn due to cardiac side effects . The leading causes of cardiac toxicity is blocking the fast delayed rectifier current (IKr), prolonging the QT interval in the duration of a cardiac action potential, and then inducing torsade de pointe (TDP), which can cause sudden death in severe cases.…”

Section: Resultsmentioning

confidence: 99%

Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma

Zhang

Chen

et al. 2022

J. Med. Chem.

View full text Add to dashboard Cite

KRAS mutations (G12C, G12D, etc.) are implicated in the oncogenesis and progression of many refractory cancers. Son of sevenless homolog 1 (SOS1) is a key regulator of KRAS to modulate KRAS from inactive to active states. Herein, we disclosed efficacy-improving tetra-cyclic quinazoline derivatives as an enhanced scaffold for inhibiting the SOS1–KRAS interaction. Compound 37, which conjugated 1-carbonitrile-cyclopropane to tetra-cyclic quinazoline, showed a twofold higher oral drug exposure and 2.5-fold longer half-life than BI-3406 in CD-1 mouse plasma. In a Mia-paca-2 xenograft model, 37 administrated alone inhibited tumor growth by 71%. Preclinical investigations demonstrated that 37 had a limited inhibition of CYP and hERG. Overall, our studies showed that 37 was a promising drug candidate for treatment of KRAS-driven cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma

Zhang

Chen

et al. 2022

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

“…Knowledge and understanding of etiological factors and conditions enables the physical education teacher to form a risk group of children whom he can purposefully observe (the concept is dynamic health-preserving observation), more carefully and individually develop and select physical exercises and training regimens, preventing risky physical exertion , and take into account the risks for children's cardiac health. of life-threatening arrhythmias (disruption of the heart rhythm), "malignant arrhythmias", which can lead to fibrillation (uneven, asynchronous contraction of the heart muscle), heart flutter and quick death These life-threatening arrhythmias arise as a result of disturbances in the nervous system of the heart, which, in turn, are formed under the influence of various (presented above) etiological factors [14][15][16][17]. Other aspects and mechanisms of pathogenesis are also studied, among which an important role is given to hemodynamics [4].…”

Section: • Circuit Trainingmentioning

confidence: 99%

“…Tse et al [17] on the basis of morphological studies of the Stellate ganglion, a preliminary conclusion was made about the connection of inflammation in the specified sympathetic structures with sudden cardiac death.…”

Section: Introductionmentioning

confidence: 99%

Technologization of sudden cardiac death prevention based on the disciplinary-methodological matrix of health-preserving competence

Fedorets,

Klochko

2023

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

The article presents the educational meta-technology of the disciplinary-methodological matrix of the health-preserving competence of the physical education teacher using the example of the prevention of sudden cardiac death during physical exertion. The disciplinary-methodical matrix is considered as a cognitive-value-educational and anthropoculturally oriented metatechnology developed by integrating various disciplines (and their systems) (mainly anthropologically and health-preserving oriented), systems of knowledge, discourses and narratives, ideas, values, meanings, methods and problematization and conceptualization strategies, etc. An actual aspect of this technology is the purposeful development of methodical disciplines in which attention is purposefully focused on a certain aspect of learning. The basis of the “Etiological method of prevention of sudden cardiac death” is the idea of an etiological (causal) approach actualized within the framework of the methodical discipline “Patopedagogy” formed on the basis of the transfer of knowledge from the medical science of pathology. As a result of an experimental study aimed at studying the dynamics of the formation of the cognitive and cognitive ability of physical education teachers for the prevention of sudden cardiac death, the positive dynamics of educational results is determined. This depends on the effectiveness of the application of the disciplinary-methodological matrix of health-preserving competence in physical education teacher. The necessary disciplinary and methodological matrices can be constructed for the formation of various competencies and goals and design of training.

show abstract

Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model

Zhou

Liu

et al. 2022

Basic Res Cardiol

View full text Add to dashboard Cite

Sudden cardiac deaths have higher proportion of left stellate ganglionitis

Cited by 5 publications

References 30 publications

Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma

Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma

Technologization of sudden cardiac death prevention based on the disciplinary-methodological matrix of health-preserving competence

Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model

Contact Info

Product

Resources

About