Sudden cardiac death early after ST elevation myocardial infarction with and without severe left ventricular dysfunction

Chitnis, Nishad; Vooturi, Sudhindra; Rao, B. Hygriv

doi:10.1016/j.ihj.2014.10.416

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…In patients post MI, 16 studies were identified involving a total of 250766 patients[24-39](Table 3). The absolute risk of SCD in these studies varied from around 4.9%-8%[24,26,30,33]. The absolute risk of SCD was 4.9% in the first month post-MI and decreased thereafter[24].…”

Section: Resultsmentioning

confidence: 99%

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Risk factors for sudden cardiac death to determine high risk patients in specific patient populations that may benefit from a wearable defibrillator

Khan

Leslie

2019

WJC

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BACKGROUND There is a high risk for sudden cardiac death (SCD) in certain patient groups that would not meet criteria for implantable cardioverter defibrillator (ICD) therapy. In conditions such as hypertrophic cardiomyopathy (HCM) there are clear risk scores that help define patients who are high risk for SCD and would benefit from ICD therapy. There are however many areas of uncertainty such as certain patients post myocardial infarction (MI). These patients are high risk for SCD but there is no clear tool for risk stratifying such patients. AIM To assess risk factors for sudden cardiac death in major cardiac disorders and to help select patients who might benefit from Wearable cardiac defibrillators (WCD). METHODS A literature search was performed looking for risk factors for SCD in patients post-MI, patients with left ventricular systolic dysfunction (LVSD), HCM, long QT syndrome (LQTS). There were 41 studies included and risk factors and the relative risks for SCD were compiled in table form. RESULTS We extracted data on relative risk for SCD of specific variables such as age, gender, ejection fraction. The greatest risk factors for SCD in post MI patients was the presence of diabetes [Hazard ratio (HR) 1.90-3.80], in patient with LVSD was ventricular tachycardia (Relative risk 3.50), in LQTS was a prolonged QTc (HR 36.53) and in patients with HCM was LVH greater than 20 mm (HR 3.10). A proportion of patients currently not suitable for ICD might benefit from a WCD CONCLUSION There is a very high risk of SCD post MI, in patients with LVSD, HCM and LQTS even in those who do not meet criteria for ICD implantation. These patients may be candidates for a WCD. The development of more sensitive risk calculators to predict SCD is necessary in these patients to help guide treatment.

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Section: Resultsmentioning

confidence: 99%

“…One study showed a risk of SCD of 7% at 30 d and 11% at 2 years[30]. Another study showed a risk of SCD at 4% in those with EF > 35% and 8% in those with EF < 35% at one year[33].…”

Section: Resultsmentioning

confidence: 99%

Risk factors for sudden cardiac death to determine high risk patients in specific patient populations that may benefit from a wearable defibrillator

Khan

Leslie

2019

WJC

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“…There is limited data on incidence of sudden death after an MI in India [ 8 ]. Patients suffering an MI in India are different from those in the West, principally being younger and with a higher prevalence of diabetes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sudden death and its predictors in myocardial infarction survivors in an Indian population

Selvaraj

Rangasamy

Priya

et al. 2021

Indian Pacing and Electrophysiology Journal

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Objective This study was conducted to assess the incidence of sudden cardiac death (SCD) in post myocardial infarction patients and to determine the predictive value of various risk markers in identifying cardiac mortality and SCD. Methods Left ventricular function, arrhythmias on Holter and microvolt T wave alternans (MTWA) were assessed in patients with prior myocardial infarction and ejection fraction ≤ 40%. The primary outcome was a composite of cardiac death and resuscitated cardiac arrest during follow up. Secondary outcomes included total mortality and SCD. Results Fifty-eight patients were included in the study. Eight patients (15.5%) died during a mean follow-up of 22.3 ± 6.6 months. Seven of them (12.1%) had SCD. Among the various risk markers studied, left ventricular ejection fraction (LVEF) ≤ 30% (Hazard ratio 5.6, 95% CI 1.39 to 23) and non-sustained ventricular tachycardia (NSVT) in holter (5.7, 95% CI 1.14 to 29) were significantly associated with the primary outcome in multivariate analysis. Other measures, including QRS width, heart rate variability, heart rate turbulence and MTWA showed no association. Conclusions Among patients with prior myocardial infarction and reduced left ventricular function, the rate of cardiac death was substantial, with most of these being sudden cardiac death. Both LVEF ≤30% and NSVT were associated with cardiac death whereas only LVEF predicted SCD. Other parameters did not appear useful for prediction of events in these patients. These findings have implications for decision making for the use of implantable cardioverter defibrillators for primary prevention in these patients.

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Involvement of sphingosine-1-phosphate receptors 2/3 in IR-induced sudden cardiac death

et al. 2019

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Sudden cardiac death early after ST elevation myocardial infarction with and without severe left ventricular dysfunction

Abstract: The incidence of SCD is high in first month after STEMI, irrespective of LV function. The number of SCD is higher in Group B patients. Algorithms to assess risk of SCD in early post STEMI period are urgently needed.

Cited by 4 publications

References 15 publications

Risk factors for sudden cardiac death to determine high risk patients in specific patient populations that may benefit from a wearable defibrillator

Risk factors for sudden cardiac death to determine high risk patients in specific patient populations that may benefit from a wearable defibrillator

Sudden death and its predictors in myocardial infarction survivors in an Indian population

Involvement of sphingosine-1-phosphate receptors 2/3 in IR-induced sudden cardiac death

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