Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment

Fineschi, Vittorio; Neri, Margherita; Riezzo, Irene; Turillazzi, Emanuela

doi:10.1007/s00414-004-0464-1

Cited by 35 publications

(33 citation statements)

References 13 publications

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“…In conclusion, in agreement with the literature, e.g. [6,8,9,12,13], these cases demonstrate again the importance of histological and immunohistochemical investigations in forensic casework.…”

Section: Discussionsupporting

confidence: 89%

Sudden death after isobutane sniffing: a report of two forensic cases

Pfeiffer¹,

Khaddam²,

Brinkmann³

et al. 2005

Int J Legal Med

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The intentional inhalation of a volatile substance ("sniffing") causing euphoria and hallucinations is an under-recognised form of substance abuse in children and adolescents with a high morbidity and mortality. Sudden death can be caused by cardiac arrhythmia, asphyxia or trauma. Two fatal cases of isobutane sniffing of cigarette lighter refill containing isobutane are reported. Toxicological investigations revealed the presence of isobutane in the heart blood and brain tissue of both cases (case 1: heart blood 0.1 microg/g, brain tissue 2.3 microg/g; case 2: heart blood 4.6 microg/g, brain tissue 17.4 microg/g) and the presence of its metabolite 2-methyl-2-propanol in the heart blood of both cases (0.5 and 1.8 microg/g, respectively). The histological investigations of the inner organs showed similar results in both victims. Autopsy findings, results of the histological and immunohistochemical investigations, toxicological findings and analytical procedures are discussed.

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Section: Discussionsupporting

confidence: 89%

Sudden death after isobutane sniffing: a report of two forensic cases

Pfeiffer¹,

Khaddam²,

Brinkmann³

et al. 2005

Int J Legal Med

View full text Add to dashboard Cite

show abstract

“…In agreement with the literature (e.g. Janssen 1984, Pfeiffer et al 2004, Fineschi et al 2004, this case demonstrates again the importance of histological and immunohistochemical investigations in forensic casework.…”

Section: Introductionsupporting

confidence: 87%

An unusual case of homicidal near drowning followed by electrocution

2005

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A young woman was found dead in a bath-tub with her facial orifices under water and current burn marks at the right big toe and at the neck near the hairline. Initial police investigations assumed an accidental electric shock due to a radio falling into the water. The forensic autopsy was followed by extensive histology and immunohistochemistry of the internal organs and skin marks. Intensive vital reactions of a near-drowning were detected that suggested a survival period of at least 20 min. Furthermore, an energy dispersive x-ray spectroscopy analysis on the current burn marks and on possible current applicators was performed, as well as reconstruction experiments with a cadaver of a pig that had been slaughtered shortly before. The results of all investigations revealed a two-step procedure with a primary near-drowning and a final current application with consecutive cardiac arrest.

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“…High pain threshold, decreased vomiting, temperature instability in infancy or altered temperature sensitivity in older children and adults, scoliosis and/or kyphosis, early adrenarche, osteoporosis, unusual skill with jigsaw puzzles, and normal neuromuscular studies histological hallmark of an acute adrenergic stress which could trigger a malignant arrhythmia (ventricular fibrillation) [39,40].…”

Section: Discussionmentioning

confidence: 99%

Sudden cardiac death in a child affected by Prader-Willi syndrome

et al. 2005

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A case of sudden cardiac death in a 3-year-old young male affected by Prader-Willi syndrome, clinically diagnosed and confirmed by means of DNA methylation, is presented. The infant suddenly collapsed at home and was taken apparently unconsciousness by his mother to the emergency clinic where he was pronounced dead. A complete postmortem examination was performed and the histological findings led to the definition of cardiac death with a typical picture of contraction band necrosis. Pulmonary hypoxic alterations are frequently reported as the primary cause of death in PWS cases. In this fatal case according to the macroscopic and microscopic findings, the cause of death was most likely cardiac and possibly related to contraction band necrosis linked with ventricular fibrillation and sudden death.

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Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment

Cited by 35 publications

References 13 publications

Sudden death after isobutane sniffing: a report of two forensic cases

Sudden death after isobutane sniffing: a report of two forensic cases

An unusual case of homicidal near drowning followed by electrocution

Sudden cardiac death in a child affected by Prader-Willi syndrome

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