Sudden Cardiac Arrest Without Overt Heart Disease

Modi, Simon; Krahn, Andrew D.

doi:10.1161/circulationaha.110.981381

Cited by 54 publications

(41 citation statements)

References 133 publications

(141 reference statements)

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“…26,27 A full cardiac assessment is needed in cardiac arrest survivors. 38 who have undergone rapid defibrillation after out-of-hospital cardiac arrest, however, is similar to that among age-, sex-and disease-matched patients who have not had out-of-hospital cardiac arrest, although only 40 % of survivors had an implantable cardioverter defibrillator implanted. 63 Family members of young SCD victims are at increased risk for ventricular arrhythmias and ischaemic heart disease.…”

Section: Investigations In Survivorsmentioning

confidence: 68%

“…[35][36][37] Coronary spasm is also a cause of cardiac arrest, particularly in male smokers with minimal or no pre-existing CAD. 38 Mitral valve prolapse in female patients with ECG repolarisation abnormalities, and frequent complex ventricular ectopy, has also been associated with out-of-hospital cardiac arrest. 39,40 An association between air pollution (fine particulate matter with an aerodynamic diameter <2.5 µm and ozone) and out-of-hospital cardiac arrest has recently been demonstrated.…”

Section: Department Of Defense Cardiovascular Death Registry In the Umentioning

confidence: 99%

“…Genome-wide association studies are promising but of limited clinical value. 9 The following tests are useful for establishing a diagnosis in SCD survivors: 38 • ECG (ischaemia, myocardial infarction, inherited channelopathies).…”

Section: Investigations In Survivorsmentioning

confidence: 99%

See 2 more Smart Citations

A Clinical Perspective on Sudden Cardiac Death

2016

Arrhythmia &Amp; Electrophysiology Review

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This article presents the epidemiology, aetiology and pathophysiology of sudden cardiac death. The modern management of survivors as well as of family members of victims is discussed, as are the relevant recommendations of guidelines prepared by learned societies. KeywordsOut-of-hospital cardiac arrest, sports-related sudden death, sudden cardiac death, sudden unexplained death syndrome Disclosure: The authors have no conflicts of interest to declare.

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Section: Investigations In Survivorsmentioning

confidence: 68%

Section: Department Of Defense Cardiovascular Death Registry In the Umentioning

confidence: 99%

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A Clinical Perspective on Sudden Cardiac Death

2016

Arrhythmia &Amp; Electrophysiology Review

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“…18,20 Approximately 5% to 10% of SCA victims do not have any structural abnormalities or CHD and are attributed to manifest or latent primary electric disease. 20 Among several causes, 5 important causes should be considered: (1) acquired (drugs) or inherited LQTS can result in torsades de pointe form of polymorphic VT (PMVT), (2) Brugada syndrome, (3) …”

Section: Cause Of Sca and Deathmentioning

confidence: 99%

Clinical Management and Prevention of Sudden Cardiac Death

Yousuf

Chrispin

Tomaselli

et al. 2015

Circulation Research

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Despite the revolutionary advancements in the past 3 decades in the treatment of ventricular tachyarrhythmias with device-based therapy, sudden cardiac death (SCD) remains an enormous public health burden. Survivors of SCD are generally at high risk for recurrent events. The clinical management of such patients requires a multidisciplinary approach from postresuscitative care to a thorough cardiovascular investigation in an attempt to identify the underlying substrate, with potential to eliminate or modify the triggers through catheter ablation and ultimately an implantable cardioverter-defibrillator (ICD) for prompt treatment of recurrences in those at risk. Early recognition of low left ventricular ejection fraction as a strong predictor of death and association of ventricular arrhythmias with sudden death led to significant investigation with antiarrhythmic drugs. The lack of efficacy and the proarrhythmic effects of drugs catalyzed the development and investigation of the ICD through several major clinical trials that proved the efficacy of ICD as a bedrock tool to detect and promptly treat life-threatening arrhythmias. The ICD therapy is routinely used for primary prevention of SCD in patients with cardiomyopathy and high risk inherited arrhythmic conditions and secondary prevention in survivors of sudden cardiac arrest. This compendium will review the clinical management of those surviving SCD and discuss landmark studies of antiarrhythmic drugs, ICD, and cardiac resynchronization therapy in the primary and secondary prevention of SCD.

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“…ong QT syndrome (LQTS), affecting approximately 1 in 2000 people, 1 is defined as a group of genetically distinct arrhythmogenic disorders resulting in abnormal cardiac sodium and potassium ion channels causing delayed repolarization of the heart. 2 This syndrome can present clinically as syncope, seizures, or sudden cardiac death secondary to its characteristic ventricular arrhythmia of torsades de pointes.…”

mentioning

confidence: 99%

Concealed Long QT Syndrome and Intractable Partial Epilepsy: A Case Report

Anderson

Bos

Meyer

et al. 2012

Mayo Clinic Proceedings

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Herein, we describe a patient with concealed type 2 long QT syndrome with concomitant electroencephalogramdocumented epilepsy. Although syncope in patients with long QT syndrome is common and often secondary to cerebral hypoxia after a protracted ventricular arrhythmia, this article demonstrates the importance of avoiding "tunnel vision" as patients with long QT syndrome could also have a primary seizure disorder. Identification of the etiology underlying seizurelike activity is paramount in instituting effective therapy. Furthermore, we theorize that abnormal KCHN2-encoded potassium channel repolarization in the brain could result in epilepsy and arrhythmias in long QT syndrome.

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Sudden Cardiac Arrest Without Overt Heart Disease

Cited by 54 publications

References 133 publications

A Clinical Perspective on Sudden Cardiac Death

A Clinical Perspective on Sudden Cardiac Death

Clinical Management and Prevention of Sudden Cardiac Death

Concealed Long QT Syndrome and Intractable Partial Epilepsy: A Case Report

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