Sudden bilateral sensorineural hearing loss after intravenous cocaine injection: A case report and review of the literature

Stenner, Markus; Stürmer, Konrad; Beutner, Dirk; Klußmann, Jens Peter

doi:10.1002/lary.20711

Cited by 19 publications

(31 citation statements)

References 13 publications

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“…In a large nationally representative sample in the USA, among 35-49 years old people, a positive association between duration of some illicit drugs use and tinnitus was observed. [19] Illicit drugs may increase the chance for tinnitus for 2.4 times. This effect may be explained by fluctuations in the blood supply of cochlea or by dysregulation of cochlear N-methyl-D-aspartate receptors and aberrant firing of the auditory nerve as a direct ototoxic effect of illicit drugs.…”

Section: Discussionmentioning

confidence: 99%

“…[5] The association between use of various illicit drugs and hearing impairment or damage was described in several clinical and epidemiological studies. [16][17][18][19][20] Sudden sensorineural hearing loss, presumably of cochlear origin, may be a rare complication of incident drug abuse, [21,22] whereas chronic tinnitus is connected with the duration of inhalant and hallucinogen drug dependence. [20] Alcohol consumption among adolescents may also be associated with tinnitus.…”

Section: Introductionmentioning

confidence: 99%

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Tinnitus among Serbian secondary school students in relation to their behavior and habits

et al. 2014

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Although tinnitus is a very common symptom, risk factors related to behavior and habits have not been sufficiently investigated. As no investigation on this problem has been performed in Serbia, the aim of our study was to establish the prevalence of tinnitus among Serbian adolescents and to investigate the relationship between their behavior and habits and tinnitus. This investigation was designed as a cross-sectional interview study among secondary school students in Belgrade, Serbia (277 boys and 494 girls). An anonymous questionnaire was self-administered at classes. The investigated variables were: The presence of tinnitus, sources of noise, night outs at noisy places, use of personal music players, smoking, second hand smoke (SHS), substance abuse, coffee and alcohol consumption. Spearman's rank-order correlations and multiple logistic regressions were performed with variables related to behavior and habits as independent ones and tinnitus as a dichotomized dependent variable. Tinnitus was reported by 99 students (12.8%), more frequently among girls compared with boys (P = 0.009). Multivariate logistic regression analysis in boys revealed a significant independent effect of a regular drug abuse on the onset of tinnitus. The chances of tinnitus were 13 times higher among drug addicts compared with non-drug users (odds ratio [OR] and 95% confidence interval [CI] for tinnitus = 13.072; 1.335-127.946). In girls, the significant independent effect on tinnitus was found for daily duration of exposure to SHS (OR and 95% CI for tinnitus = 1.328; 1.073-1.644 /per 2 hours of exposure/).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tinnitus among Serbian secondary school students in relation to their behavior and habits

et al. 2014

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“…Heroin, cocaine, and methadone use, on the other hand, has been linked to profound hearing loss that is reversible in some cases and irreversible in others. The literature varies on the route of administration, ranging from intravenous injection to oral consumption to inhalation, as well as on the amount and duration of use, ranging from the first episode of use to chronic use lasting over 20 years (Christenson and Marjala, 2010; Ciorba et al, 2009; Fowler and King, 2008; Friedman et al, 2000; Harell et al, 1978; Ho et al, 2007; Iqbal, 2004; Ishiyama et al, 2001; Oh et al, 2000; Rigby and Parnes, 2008; Schrock et al, 2008; Stenner et al, 2009; van Gaalen et al, 2009). Some patients have recovered their hearing after a course of steroids and pentoxifylline, while others have recovered spontaneously, usually within one month of onset.…”

Section: Discussionmentioning

confidence: 99%

“…A less well-known adverse effect of opioids is sudden or rapidly-progressive sensorineural hearing loss. Multiple reports have linked hydrocodone/acetaminophen, oxycodone/acetaminophen, propoxyphene, heroin, cocaine, methadone, and amphetamine use with severe to profound sensorineural hearing loss (Christenson and Marjala, 2010; Ciorba et al, 2009; Fowler and King, 2008; Friedman et al, 2000; Harell et al, 1978; Ho et al, 2007; Iqbal, 2004; Ishiyama et al, 2001; Oh et al, 2000; Rigby and Parnes, 2008; Schrock et al, 2008; Stenner et al, 2009; van Gaalen et al, 2009). Some of these studies reported individuals that used legally-prescribed medications, such as Vicodin, not always at high doses, but sometimes within the recommended dosages.…”

Section: Introductionmentioning

confidence: 99%

Mu-opioid receptor (MOR) expression in the human spiral ganglia

et al. 2014

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Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in the human and mouse spiral ganglia (SG) and organ of Corti. In the human most of the (SG) neurons were immunoreactive; a subset was non-immunoreactive. In situ hybridization revealed a similar labeling pattern across the neurons of the SG. A similar distribution MOR pattern was demonstrated in the mouse SG. In the mouse organ of Corti MOR was expressed in inner and outer hair cells. Fibers underneath the inner hair cells were also MOR immunoreactive. These results are consistent with a role of MOR in neuro-modulation of the auditory periphery. The present results show that the expression of MORs is well-conserved across multiple mammalian species, indicative of an important role in auditory processing.

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“…The onset of bilateral deafness following heroin relapse may indicate a resensitization of a tolerized opioid system or possible hypersensitization of the system secondary to withdrawal. 47 Stenner et al 52 reported one case of bilateral severe SSNHL (with no tinnitus or vertigo) in a 26-year-old patient after cocaine abuse (intravenous twice, 50 mg/mL). Ear, nose, and throat examination and tympanograms were normal for both ears.…”

Section: Hydrocodone and Ssnhlmentioning

confidence: 99%

Sudden Sensorineural Hearing Loss Due to Drug Abuse

López¹,

Ishiyama²,

Ishiyama

2012

Semin Hear

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In the last 10 years, there has been an emergence of reports related to opioid-induced sudden sensorineural hearing loss (SSNHL). The underlying pathology is not completely understood, and the mechanism(s) of action of these drugs in the inner ear remains to be determined. Reports of SSNHL due to the abuse of opioid peptides and other drugs suggest that the opioid system in the inner ear is affected. The reversible or irreversible effect on auditory function depends on the type of drug used and several other factors, including duration and time of exposure as well as the health status of drug users. Abuse of hydrocodone + acetaminophen (Vicodin 1 hydrocodone/paracetamol; Abbott Laboratories, Worcester, MA) has induced permanent hearing loss in several individuals. In contrast, abuse of heroin-induced hearing loss that was sometimes reversible. The widespread expression and physiological action of endogenous peptide opioids and their receptors in the inner ear suggests that pharmacological treatment for druginduced hearing loss is possible. The present study reviews the basic concepts of opioids and their receptors, provides clinical examples of hearing loss mediated by opioids and related drugs, reviews experimental evidence of the presence of opioids and their receptors in the inner ear (animal models and human studies), and describes the cellular targets affected by opioids and other recreational drugs.Learning Outcomes: As a result of this activity, the participant will be able to (1) identify the recreational drugs that cause sudden sensorineural hearing loss, (2) describe the possible sites and mechanism of action of these drugs in the inner ear, (3) differentiate between the types of recreational drugs that cause permanent or temporary hearing loss, (4) describe the treatments that clinicians have used when hearing loss is caused by opioids and other drugs.

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Sudden bilateral sensorineural hearing loss after intravenous cocaine injection: A case report and review of the literature

Cited by 19 publications

References 13 publications

Tinnitus among Serbian secondary school students in relation to their behavior and habits

Tinnitus among Serbian secondary school students in relation to their behavior and habits

Mu-opioid receptor (MOR) expression in the human spiral ganglia

Sudden Sensorineural Hearing Loss Due to Drug Abuse

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