I n the mid-1990s, researchers at the National Institute of Mental Health (NIMH) identified a link between recent streptococcal infection and the development of neuropsychiatric symptoms such as separation anxiety, tics, behavioral regression, rage, restricted eating, and obsessive-compulsive disorder (OCD;Swedo et al., 1998).
ETIOLOGYResearch has found that in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS), exposure to an infection or other agent that activates the immune system creates an immune response that goes awry, causing autoantibodies (or immune cells) to attack brain cells instead (Chang et al., 2015;Platt et al., 2017). The resulting inflammation causes obsessions, compulsions, hallucinations, restricted eating, motor difficulties and tics, behavioral challenges, and other symptoms. PANDAS and PANS typically have a distinct onset (Chang et al., 2015); however, if symptoms are mild at first, parents and clinicians may initially overlook the change in behavior as part of typical development (Rice Doran, 2016b).