Sudanese Lipid Profile in Diabetics and Non-Diabetics - Central Sudan-2013

Abstract

Objectives: To find out the association of type 2 diabetes mellitus (T2DM) with increased risk of dyslipidemia and cardiovascular disease in Sudanese population, glucose, lipid profile as well as blood pressure were measured. Materials and Method: A case-control study was made at Gezira State, Sudan, during the period of April 2012-March 2013. A total of two hundred matching inclusion criteria were enrolled in the study, participants divided into diabetic and non-diabetic groups to estimate the levels of FPG, Glycosylated hemoglobin HbA1c and lipid profile (TC, HDL-C, LDL-C, and TG). Samples were analyzed for different biochemical parameters, using A15, a random access auto-analyzer bio system. A questionnaire including personal information was filled as well as anthropometric and biochemical measures. Verbal consent obtain from each respondent then venous blood was collected after an overnight fast. Statistical analysis was carried-out using statistical package for social sciences (SPSS version 16, Chicago, IL, USA). Result: Tukey- HSD test showed that BMI, SBP and DBP increased significantly by (0.001), (0.017) and (0.032) respectively. FPG and HbA1c were increased with highly significant (p=>0.0001). TC, HDL-C and LDL-C showed non-significant increase in their mean concentrations (196.28), (54.28) and (105.75) respectively. TG mean concentration was (158.86) had increased significant (0.057). Conclusion: Study showed significant increase in BMI. Lipid profile of study participants showed no differences in TC and LDL-C and HDL-C, but TG showed significant increased. Systolic (SBP) and diastolic (DBP) blood pressure showed significant increase in all study participants. Study population with T2DM was at high risk to develop metabolic syndrome.