Sucrose exposure in juvenile rats produces long-term changes in fear memory and anxiety-like behavior

Kruse, María Sol; Vadillo, Martín Javier; Fernandez, Anabel; Rey, Mariana; Zanutto, B. Silvano; Coirini, Héctor

doi:10.1016/j.psyneuen.2019.03.016

Cited by 14 publications

(27 citation statements)

References 45 publications

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“…Similar to our CAF rats, an anxiety-like phenotype was not seen in the SUG cohorts, which is consistent with our previous findings in male rats using the Zero Maze test [15]. However, other studies have reported an anxiety-like phenotype in the open field test in male rodents after switching to standard chow for 1 week following an adolescent CAF diet [51] and after adolescent SUG exposure even after removing the sugar access for 25 days in young adulthood [29]. Thus, it is possible that the detection of anxiety-like behavior after WD exposure may be more or less sensitive depending on the type of behavioral test used.…”

Section: Discussionsupporting

confidence: 92%

“…Experiment 1B: A second cohort of female rats (n = 31, 50-70 g) was treated as described above in order to collect behavioral data following the dietary intervention. These rats were tested on NOIC after 5 weeks of dietary intervention (chow and water only) at PN 101 and Zero Maze at PN 108 (Figure 1B), with the interventional timeframe being similarly adapted from other studies that evaluated the metabolic and neurocognitive effects of WD consumption after dietary intervention [28,29]. Fecal samples for microbiota analyses were collected after the dietary intervention at PN 106 (n = 15 CHOW group, n = 16 CAF group).…”

Section: Experiments 1 Design (Junk Food-style Cafeteria Diet)mentioning

confidence: 99%

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Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Tsan

Sun

Hayes

et al. 2021

Nutritional Neuroscience

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Section: Discussionsupporting

confidence: 92%

Section: Experiments 1 Design (Junk Food-style Cafeteria Diet)mentioning

confidence: 99%

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Tsan

Sun

Hayes

et al. 2021

Nutritional Neuroscience

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show abstract

“…Similar to our CAF rats, an anxiety-like phenotype was not seen in the SUG cohorts, which is consistent with our previous findings in male rats using the Zero Maze test (Hsu et al, 2015b;Noble et al, 2019). However, other studies have reported an anxiety-like phenotype in the open field test in male rodents after switching to standard chow for 1 week following an adolescent CAF diet (Lalanza et al, 2014) and after adolescent SUG exposure even after removing the sugar access for 25 days in young adulthood (Kruse et al, 2019). Thus, it is possible that the detection of anxiety-like behavior after WD exposure may be more or less sensitive depending on the type of behavioral test used.…”

Section: Discussionsupporting

confidence: 92%

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Tsan

Sun

Bridi

et al. 2021

Preprint

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Objective: Consumption of a Western diet during adolescence results in hippocampus (HPC)- dependent memory impairments and gut microbiome dysbiosis. Whether these adverse outcomes are reversible in adulthood following intervention with a healthy diet is unknown. Here we assessed the short- and long-term effects of adolescent consumption of a Western diet enriched with either sugar alone, or sugar and fat on metabolic outcomes, HPC-dependent memory, and gut microbiota. Methods: Adolescent female rats (PN 26) were fed a standard chow diet (CTL), a chow diet with access to 11% sugar solution (SUG), or a junk food cafeteria-style diet (CAF) containing a variety of fat- and/or sugar-enriched foods. During adulthood (PN 65+), metabolic outcomes, HPC-dependent memory, and gut microbial populations were evaluated both before and after a 5-week dietary intervention period where all groups were fed a diet of water standard chow. Results: Prior to the dietary intervention both the CAF and SUG groups demonstrated impaired HPC-dependent memory, increased adiposity, and altered gut microbial populations relative to controls. However, impaired peripheral glucose regulation was only observed in the SUG group. The dietary intervention reversed the metabolic dysfunction in both the CAF and SUG groups, whereas HPC-dependent memory impairments were reversed in the SUG, but not the CAF group. The composition of the gut microbiota remained distinct from controls in both groups after dietary intervention. Conclusions: While the metabolic impairments associated with adolescent cafeteria diet consumption are reversible in adulthood with dietary intervention, the HPC-dependent memory impairments and the gut microbiome dysbiosis persist.

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“…Overconsumption of SSBs is directly associated with the development of obesity, type 2 diabetes, and cardiovascular disease in large epidemiological studies [ 4 , 5 , 6 ]. Moreover, emerging research indicates that SSBs impair brain functioning even in the absence of extreme weight gain or excessive energy intake [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats

et al. 2022

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We previously described that excessive consumption of sucrose during youth produces fear memory and anxiety-like behavior in adulthood. Here, we evaluated whether high cognitive function is also affected by studying early sucrose consumption in object recognition memory (NOR). Male Sprague Dawley rats were tested for short-term, long-term, and consolidated NOR after 25 days of unlimited sucrose access in juvenile (PD 25–50) or adult age (PD 75–100). All rats spent equal time exploring the two objects during the sample phase T1. When animals were exposed for 2 h, 24 h, or 7 days to a copy of the objects presented in T1 and a novel object, the sucrose-exposed juvenile group failed to distinguish between the familiar and the novel objects in contrast with the rest of the groups. Sucrose-exposed animals developed hypertriglyceridemia and glucose intolerance, but juvenile animals showed increased fasting glycemia and sustained the glucose intolerance longer. Moreover, sucrose decreased hippocampal proBDNF expression in juveniles while it was increased in adults, and sucrose also increased RAGE expression in adults. The NOR exploration ratio correlated negatively with basal glycemia and positively with proBDNF. Taken together, these data suggest that sucrose-induced alterations in glucose metabolism may contribute to a long-term decline in proBDNF and impaired recognition memory.

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Sucrose exposure in juvenile rats produces long-term changes in fear memory and anxiety-like behavior

Cited by 14 publications

References 45 publications

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long-lasting despite healthy dietary intervention

Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats

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