Sucralose Suppresses Food Intake

Park, Scarlet J.; Carvalho, Gil B.; Murphy, Keith R.; Ehrlich, Margaux R.; Ja, William W.

doi:10.1016/j.cmet.2017.02.011

Cited by 19 publications

(8 citation statements)

References 9 publications

(19 reference statements)

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“…duration and intensity of ethanol exposure, metabolism) would impact consumptive ethanol preference. Our work adds to the body of evidence showing how changes in feeding behavior drive diverse phenotypes (Keebaugh et al, 2017;Keebaugh et al, 2018;Park et al, 2017;Yamada et al, 2017;Ja et al, 2009). Future studies, especially those focused on the psychopharmacological properties of ethanol, should test for the possibility that changes in total food intake contribute to addiction-like phenotypes.…”

Section: Resultsmentioning

confidence: 81%

Absolute ethanol intake predicts ethanol preference inDrosophila

Park

2020

Journal of Experimental Biology

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Factors that mediate ethanol preference in Drosophila melanogaster are not well understood. A major confound has been the use of diverse methods to estimate ethanol consumption. We measured fly consumptive ethanol preference on base diets varying in nutrients, taste and ethanol concentration. Both sexes showed an ethanol preference that was abolished on high nutrient concentration diets. Additionally, manipulating total food intake without altering the nutritive value of the base diet or the ethanol concentration was sufficient to evoke or eliminate ethanol preference. Absolute ethanol intake and food volume consumed were stronger predictors of ethanol preference than caloric intake or the dietary caloric content. Our findings suggest that the effect of the base diet on ethanol preference is largely mediated by total consumption associated with the delivery medium, which ultimately determines the level of ethanol intake. We speculate that a physiologically relevant threshold for ethanol intake is essential for preferential ethanol consumption.

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Section: Resultsmentioning

confidence: 81%

Absolute ethanol intake predicts ethanol preference inDrosophila

Park

2020

Journal of Experimental Biology

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“…Larval diet composition impacts adult food choice ( Davies et al, 2018 ), and preference of a caloric diet over an equally palatable alternative is only established after several hours ( Dus et al, 2011 ; Stafford et al, 2012 ). Similarly, a dietary imbalance between palatability and nutritional content is leading to sustained physiological changes much later ( Wang et al, 2016 , 2017 ; Musso et al, 2017 ; Park et al, 2017 ; May et al, 2019 ). Apart from few exceptions ( Martin, 2004 ; Meunier et al, 2007 ), most existing fly locomotion studies either examine short periods at high temporal resolution ( Kim and Dickinson, 2017 ; Murata et al, 2017 ; Brockmann et al, 2018 ; Hughson et al, 2018 ; Landayan et al, 2018 ), or sample for short recurring time windows to cover longer periods ( Green, 1964a , b ; Connolly, 1966a ; Barwell et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Mahishi

Triphan

Hesse

et al. 2021

Front. Behav. Neurosci.

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Animal behaviours are demonstrably governed by sensory stimulation, previous experience and internal states like hunger. With increasing hunger, priorities shift towards foraging and feeding. During foraging, flies are known to employ efficient path integration strategies. However, general long-term activity patterns for both hungry and satiated flies in conditions of foraging remain to be better understood. Similarly, little is known about how permanent contact chemosensory stimulation affects locomotion. To address these questions, we have developed a novel, simplistic fly activity tracking setup—the Panopticon. Using a 3D-printed Petri dish inset, our assay allows recording of walking behaviour, of several flies in parallel, with all arena surfaces covered by a uniform substrate layer. We tested two constellations of providing food: (i) in single patches and (ii) omnipresent within the substrate layer. Fly tracking is done with FIJI, further assessment, analysis and presentation is done with a custom-built MATLAB analysis framework. We find that starvation history leads to a long-lasting reduction in locomotion, as well as a delayed place preference for food patches which seems to be not driven by immediate hunger motivation.

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“…Larval diet composition impacts adult food choice (Davies et al, 2018), and preference of a caloric diet over an equally palatable alternative is only established after several hours (Dus et al, 2011;Stafford et al, 2012). Similarly, a dietary imbalance between palatability and nutritional content is leading to sustained physiological changes much later (Wang et al, 2016(Wang et al, , 2017Musso et al, 2017;Park et al, 2017;May et al, 2019). Apart from few exceptions (Martin, 2004;Meunier et al, 2007), most existing fly locomotion studies either examine short periods at high temporal resolution (Kim and Dickinson, 2017;Murata et al, 2017;Brockmann et al, 2018;Hughson et al, 2018;Landayan et al, 2018), or sample for short recurring time windows to cover longer periods (Green, 1964a(Green, , 1964bConnolly, 1966a; Barwell et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Long-lasting impact of starvation experience on fly activity and place preference

Mahishi

Triphan

Hesse

et al. 2020

Preprint

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Animal behaviours are demonstrably governed by sensory stimulation, previous experience and internal states like hunger. With increasing hunger, priorities shift towards foraging and feeding. During foraging, flies are known to employ efficient path integration strategies. However, general long-term activity patterns for both hungry and satiated flies in conditions of foraging remain to be better understood. Similarly, little is known about how chronic contact chemosensory stimulation affects locomotion. To address these questions, we have developed a novel, simplistic fly activity tracking setup – the Panopticon. Using a 3D-printed Petri dish inset, our assay allows recording of walking behaviour, of several flies in parallel, with all arena surfaces covered by a uniform substrate layer. We tested two constellations of providing food: i) in single patches, and ii) omnipresent within the substrate layer. Fly tracking is done with FIJI, further assessment, analysis and presentation is done with a custom-built MATLAB analysis framework. We find that starvation history leads to a long-lasting reduction in locomotion, as well as a delayed place preference for food patches not driven by immediate hunger motivation.

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Sucralose Suppresses Food Intake

Cited by 19 publications

References 9 publications

Absolute ethanol intake predicts ethanol preference inDrosophila

Absolute ethanol intake predicts ethanol preference inDrosophila

The Panopticon—Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference

Long-lasting impact of starvation experience on fly activity and place preference

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