Sucralfate—Warfarin Interaction

The effect of food on the interaction of ofloxacin with sucralfate in healthy volunteers

“…Therefore, quinolone-metal cation interactions could not only be accounted for by chelate formation. Another mechanism could be adsorption on to antacids or insolubility in neutralized gastric acid [18,19]. However, the systemic availability of DR-3355, the S(-)-enantiomer of ofloxacin, was not influenced by calcium carbonate and oral ranitidine, indicating that changes in gastric pH do not affect the absorption of DR-3355 [6].…”

Topical sucralfate for treatment of mucocutaneous conditions: A systematic review on clinical evidences

“…Uncontrolled diabetes, advanced kidney diseases, and sensitivity to the drug are the only contraindications for its use. 1,[3][4][5] Even though exact sucralfate in-vivo mechanisms of action remain unknown, in-vitro studies have suggested the seven following mechanisms: 1. inhibition of bacterial activity; 2. reducing oxygen-free radical generation; 3. the effects on arachidonic acid metabolism and increasing prostaglandin release by activating macrophages, cyclooxygenase activity, synthesis, and release of leukotriene C4; 4. decreasing cell apoptosis; 5. enhancing growth factor bioavailability; 6. the effects as a site-protective agent through providing a physical barrier; 7. the effects on tissue growth, regeneration, and repair: facilitating blood flow, cell proliferation, and repair via binding growth factors to tissues 6,7 (Figure 1). In addition to systemic sucralfate, a topical form of drug efficacy has been evaluated in several mucocutaneous indications as clinical and case studies.…”