Succinylcholine (Succinoylcholine) Muscle-Relaxant of Short Action

Bourne, J. G.

doi:10.1016/s0140-6736(52)92058-8

Cited by 188 publications

(45 citation statements)

References 2 publications

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“…Suxamethonium is a depolarizing neuromuscular blocker with a unique combination of rapid onset (ϳ45 s) and short duration of action (2-6 min in most patients). Rapid hydrolysis by BChE in plasma means that only a small proportion of an intravenous dose reaches the neuromuscular end-plate (Bourne et al, 1952;Evans et al, 1952), and the effect of the BChE that does is terminated by diffusion away from the end-plate (Kalow and Grant, 2001). Since the 1950s, many reports have confirmed the link between inherited BChE deficiency and "scoline apnea", in which paralysis persisted for 20 to 40 min, or more (Evans et al, 1952;Gould, 1952;Harper, 1952).…”

Section: B Butyrylcholinesterasementioning

confidence: 99%

Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice

2006

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Section: B Butyrylcholinesterasementioning

confidence: 99%

Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice

2006

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“…Suxamethonium was first recognised as a neuromuscular blocking agent in 1949 and it was only 3 years later that its short action was ascribed to its rapid enzymatic destruction by plasma cholinesterase [30]. This degradation is in two stages, first of all to the monocholine ester of succinic acid, succinylmonocholine, then, with a further loss of a choline molecule, to succinic acid [16].…”

Section: Suxamethoniummentioning

confidence: 99%

“…There were patients who had been classified as normal homozygotes on the basis of their dibucaine numbers (in the range 71-80) who had an unexpected low fluoride number (in the range 50-55). There were also patients who had been designated heterozygotes on their dibucaine numbers (52-60) who had much lower fluoride numbers (26)(27)(28)(29)(30)(31)(32)(33)(34). Family studies confirmed that there was a third gene which was able to influence the character of the cholinesterase gene and the patients who did not fit the correlation described were in reality carriers of this fluoride-resistant gene; instead of U/U and U/A they become U/F and A/F, respectively.…”

Section: Inherited Variationsmentioning

confidence: 99%

Cholinesterase Its significance in anaesthetic practice

1997

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SummaryPlasma cholinesterase is an enzyme which has importance to the anaesthetist primarily for its rôle in the metabolism of suxamethonium, although other anaesthetic related drugs that this enzyme metabolises are also increasingly important. In this article we review current thoughts on the function, profile and chemistry of plasma cholinesterase. Causes of variations in the activity of the enzyme are described and the basis of genetic variations is explained.

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“…Holmberg and Theslefï 5 have reported the results of its use in 512 treatments, with only one minor fracture occurring in this series. Bourne and associates 4 have reported its use in 33 patients. Balthasar and Sara°have reported its use in electroshock therapy, but the number of cases is not stated.…”

Section: 2mentioning

confidence: 99%

“…4 To date, this drug has had limited clinical trial in electroshock therapy. Holmberg and Theslefï 5 have reported the results of its use in 512 treatments, with only one minor fracture occurring in this series.…”

Section: 2mentioning

confidence: 99%

Succinylcholine Chloride in Electroshock Therapy

Wilson¹,

Nowill²

1954

AMA Arch NeurPsych

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THE PREVENTION of the complications of electroshock therapy has long been a serious problem in psychiatry. The treatment of older patients has been particularly dangerous because of the high incidence of osteoporosis, which makes the patient more susceptible to fractures, and cardiovascular disease, which makes the patient more sensitive to asphyxia. The muscle-relaxing drug curare has been extensively used since 1940,1 but its use has definite disadvantages. The action of the drug is prolonged, 10-40 minutes, and its histamine-like side-effects may result in arterial hypotension. It has practical limitations because its long action requires the time of extra personnel.Recent researches * in the use of the synthetic muscle-relaxing drugs have shown that succinylcholine chloride may be useful in electroshock therapy. This drug was first found to have muscle-relaxant effect by Bovet and co-workers in 1949.2 It is a white odorless crystalline substance which is readily soluble in water. Aqueous solutions are clear, colorless, and stable to light and temperature change. Solutions may be sterilized by autoclaving without loss of potency ; however, an alkaline pH appears to produce a chemical breakdown of the drug. The chemical formula is quite similar to that of acetylcholine. It is broken down, in vitro, by the cholinesterases probably into succinic acid and choline.In large doses the drug has a "nicotinic" effect, bringing about a rise in blood pressure.2 Only minimal histamine-like effects have been observed.4To date, this drug has had limited clinical trial in electroshock therapy. Holmberg and Theslefï 5 have reported the results of its use in 512 treatments, with only one minor fracture occurring in this series. Bourne and associates 4 have reported its use in 33 patients. Balthasar and Sara°have reported its use in electroshock therapy, but the number of cases is not stated. More recently Ardis and Wyllie T have reported the use of this drug in 2,437 treatments and now routinely use the drug in all treatments given by them.From the

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Succinylcholine (Succinoylcholine) Muscle-Relaxant of Short Action

Cited by 188 publications

References 2 publications

Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice

Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice

Cholinesterase Its significance in anaesthetic practice

Succinylcholine Chloride in Electroshock Therapy

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