Succinylcholine

Evans, Frankis T.; Gray, P.W.; Lehmann, H.; Silk, E.

doi:10.1016/s0140-6736(52)91524-9

Cited by 25 publications

(28 citation statements)

References 3 publications

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“…of SDC-C12 ( Fig. 1) Evans et al (1952) between the hydrolysis rate of acetylcholine in plasma and the sensitivity of patients to SDC. No correlation was found between the hydrolysis rate of procaine and the percentage of the administered SDC-C12 excreted in the urine.…”

Section: Methodsmentioning

confidence: 96%

“…These assumptions are indirectly favoured by the finding that, whereas there is no marked sex variation in the hydrolysis rate of acetylcholine in human plasma (Levine and Hoyt, 1949;Callaway, Davies, and Rutland, 1951), a statistically significant difference is found in the hydrolysis rate of procaine in normal male and female plasmas (Davis et al, 1953). Similarly, whereas the hydrolysis rates of acetylcholine in horse serum (Glick, 1941 ;Ginzel, Klupp, and Werner, 1951) and of succinylcholine in dog plasma (Hall, Lehmann, and Silk, 1953) were as fast or faster than that in human plasma (Evans et al, 1952;Tsuji and Foldes, 1953), the hydrolysis rate of procaine in the plasma of these species, and of other mammals, is many times slower than in human plasma (Aven, Light, and Foldes, 1953). To clarify these problems it will be necessary to study the hydrolysis rate of various substrates (acetylcholine, SDC, procaine, etc.)…”

Section: Methodsmentioning

confidence: 99%

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The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

Foldes

Norton

1954

British Journal of Pharmacology and Chemotherapy

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Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

Foldes

Norton

1954

British Journal of Pharmacology and Chemotherapy

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“…This acetylchollne analogue is an inhibitor of cholinesterase and is normally hydrolyzed by pseudocholinesterase. Patients who have a severe reaction to the drug have low levels of activity of serum pseudocholinesterase (165,166). Individuals having the defect in serum pseudocholinesterase activity have an atypical enzyme which has a higher Michaelis constant than does the normal enzyme and reacts differentially to various inhibitors (167,168).…”

Section: Hyperprol~nemla--i-iyperprollnemlamentioning

confidence: 99%

Clinical Biochemistry: Enzymatic Methods: Automation and Atomic Absorption Spectroscopy

Wacker¹,

Coombs²

1969

Annu. Rev. Biochem.

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“…(5) Cholinesterase deficiency (Evans, Gray, Lehmann, andSilk, 1952a, 1952b;Bourne, Collier, and Somers, 1952;Bourne, 1953;Hodges, 1953).…”

Section: Forms Of Neuromuscular Blockmentioning

confidence: 99%

Abnormal Responses to Muscle Relaxants in Carcinomatous Neuropathy

Croft

Vandam

1959

Survey of Anesthesiology

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We are unaware of any information concerning the mechanism by which the oxalate ion is excreted by the kidney, whether by glomerular filtration only or by a combination of glomerular filtration and renal-tubular excretion. In the latter case it is, at least theoretically, possible that either the hippurate ion or the benzoate ion, or both these, might compete with the oxalate ion for common transport mechanisms in the renal tubule epithelial cells. and that if the former ionic species were present in sufficiently high concentrations such competition would produce a decrease in the urinary oxalate excretion. The results of the experiments in which sodium benzoate was administered to normal subjects are not in accord with this explanation of the decrease in the urinary oxalate excretion which was observed when sodium benzoate was given to patients with primary hyperoxaluria. This tentative conclusion requires confirmation by the determination of the renal oxalate clearance, a procedure which will remain impracticable until the blood oxalate level can be satisfactorily determined (see above).

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Succinylcholine

Cited by 25 publications

References 3 publications

The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

The Urinary Excretion of Succinyldicholine and Succinylmonocholine in Man*

Clinical Biochemistry: Enzymatic Methods: Automation and Atomic Absorption Spectroscopy

Abnormal Responses to Muscle Relaxants in Carcinomatous Neuropathy

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