Succinylcholine Chloride

Foss, Penelope R.B.; Benezra, Steven A.

doi:10.1016/s0099-5428(08)60655-3

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Second, it is possible that our methods did not allow suxamethonium to pass the BBB. We did not measure the passage of suxamethonium across the BBB, but assumed that BBB disruption sufficient to allow the passage of Evans blue dye (charged; anhydrous molecular weight 961 Da before binding with proteins; molecular weight of dye-albumin complex approximately 68 500 Da [9]) would also permit the passage of suxamethonium (charged; anhydrous molecular weight 361 Da; hydrated molecular weight 397 Da [14]). Thus direct passage of suxamethonium across the BBB was likely to have occurred.…”

Section: Discussionmentioning

confidence: 99%

Effects of Suxamethonium on the Cerebrum Following Disruption of the Blood-Brain Barrier in Dogs

Lanier

Milde

Sharbrough

1990

British Journal of Anaesthesia

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We have studied the effects of suxamethonium 1.0 mg kg-1 i.v. on cerebral blood flow (CBF), cerebral metabolic rate (CMRO2), and the electroencephalogram (EEG) in dogs anaesthetized with halothane (1.0 MAC) following blood-brain barrier (BBB) disruption with intracarotid (i.c.) mannitol. The combination produced a transient increase in CBF, while CMRO2 did not change. These responses were similar to those produced by i.c. mannitol plus i.v. saline. Suxamethonium produced desynchronization of the EEG that persisted longer than that produced by saline. In only one of the six animals was the desynchronization sustained (90 min) beyond that found in dogs with a normal BBB. We conclude that disruption of the BBB did not enhance the cerebral stimulating effects of i.v. suxamethonium, and did not increase the likelihood of seizure activity following suxamethonium.

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Section: Discussionmentioning

confidence: 99%