Succinylated Bacterial Cellulose Induce Carbonated Hydroxyapatite Deposition in a Solution Mimicking Body Fluid

Nurlidar, Farah; Kobayashi, Mime

doi:10.22146/ijc.35048

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…6. This indicates that PEG, which is degraded first on the surface of the HAp-PEG and HAP composites, helps inhibit degradation [24][25]. The interface is a space for water and solvent.…”

Section: Degradation Testmentioning

confidence: 99%

Synthesis of Hydroxyapatite-Polyethylene Glycol with In-Situ Method Using Calcium Oxide from Blood Shells (Anadara granosa)

Jamarun,

Trycahyani,

Arief

et al. 2023

Indones. J. Chem.

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Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is a calcium phosphate-based biomaterial that is widely used in bone implants due to its similarity in composition with the constituent elements of bone. However, HAp still has poor mechanical properties, so research was carried out to improve the mechanical properties such as reduced brittleness, less fracture resistance, and a denser structure of HAp by synthesizing composites with PEG. This study used PEG as a filler and HAp as a matrix. HAp was synthesized from blood clam shells (Anadara granosa) using the sol-gel method. HAp-PEG composite was synthesized using the in-situ method with various HAp concentrations of 40, 50, 60, 70, and 80%. FTIR characterization showed the presence of functional groups PO43− and CO23−, which indicated the presence of HAp. Analysis of the XRD pattern showed a crystal size of 24.194 nm. SEM-EDX showed the needle-shaped HAp-PEG composite HAp crystal morphology and obtained a Ca/P ratio of 1.87. Analysis of DTA results showed a weight loss of 65.72% in the composite at a temperature > 200 °C. A degradation test was also carried out to see the percentage of the HAp-PEG composite to be degraded, and the optimum degraded composite with increasing days had a concentration of 70%.

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“…6. This indicates that PEG, which is degraded first on the surface of the HAp-PEG and HAP composites, helps inhibit degradation [24][25]. The interface is a space for water and solvent.…”

Section: Degradation Testmentioning

confidence: 99%

Synthesis of Hydroxyapatite-Polyethylene Glycol with In-Situ Method Using Calcium Oxide from Blood Shells (Anadara granosa)

Jamarun,

Trycahyani,

Arief

et al. 2023

Indones. J. Chem.

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“…Biocompatibility is a critical feature of 3D scaffolds designed for biomedical purposes. Furthermore, the 3D scaffolds must be biocompatible with the surrounding cells [7].…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of Sensitive pH on Hydroxyapatite Properties Synthesized from Chicken Eggshell

et al. 2022

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The hydrothermal method has effectively synthesized hydroxyapatite (HA). This study aimed to analyze the effect of pH on the properties (purity, crystallinity, and size) of HA crystals. HA synthesis of chicken eggshells was carried out using the hydrothermal method at temperatures of 230 °C with pH 9 and 9.34. The characteristics of HA are determined by XRF, XRD, FTIR, and TEM. The composition of the most significant compound obtained from the results of XRF analysis is CaO (97.5%). The XRD analysis showed that the purity of HA with pH 9.00 and 9.34 obtained was 97.8 and 96.6%, with the crystallinity of 56.46 and 56.96%. It was also obtained that the size of crystal HA was 21.8 and 15.7 nm for samples synthesized at pH 9.00 and 9.34. The results showed that the purity and size of HA were affected by differences in the pH synthesis and were relatively the same for its crystallinity which directly affects the value lattice parameter. The properties of HA produced by the hydrothermal method have met the criteria for biomedical applications.

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“…Modified BC, hyaluronic acid, and gelatin scaffolds showed promising results when they were used as scaffolds for a human glioblastoma cancer cell line [11]. In addition, modification of BC with the succinyl group has been shown to enhance BC's ability to incorporate bone-like hydroxyapatite [14].…”

Section: ■ Introductionmentioning

confidence: 99%

Gamma-Irradiated Bacterial Cellulose as a Three-Dimensional Scaffold for Osteogenic Differentiation of Rat Bone Marrow Stromal Cells

et al. 2022

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The effect of gamma-irradiation on bacterial cellulose (BC) was investigated in terms of improving its properties as scaffolds for tissue engineering. BC pellicles were exposed to 25, 50, and 75 kGy gamma-ray irradiation, and X-ray diffraction analyses showed that the crystallinity of the BC decreased as stronger irradiation accelerated BC’s degradation. Fourier transform infrared spectroscopy of the irradiated BC revealed the appearance of a new peak at 1724 cm–1, indicating the formation of a new carbonyl group due to the cleavage of glycosidic linkages of the BC. Rat bone marrow stromal cells seeded on the gamma-irradiated BC incubated in an osteogenic medium for 14 days produced calcium, a late marker for osteogenic differentiation, as shown by Alizarin Red S (ARS) staining. Gamma-irradiated BC with higher irradiation doses showed intense ARS staining indicating higher calcium deposition. These findings demonstrate the feasibility of using gamma-irradiated BC as a cytocompatible 3D scaffold for bone tissue regeneration.

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Succinylated Bacterial Cellulose Induce Carbonated Hydroxyapatite Deposition in a Solution Mimicking Body Fluid

Cited by 3 publications

References 20 publications

Synthesis of Hydroxyapatite-Polyethylene Glycol with <i>In-Situ</i> Method Using Calcium Oxide from Blood Shells (<i>Anadara granosa</i>)

Synthesis of Hydroxyapatite-Polyethylene Glycol with <i>In-Situ</i> Method Using Calcium Oxide from Blood Shells (<i>Anadara granosa</i>)

Effect of Sensitive pH on Hydroxyapatite Properties Synthesized from Chicken Eggshell

Gamma-Irradiated Bacterial Cellulose as a Three-Dimensional Scaffold for Osteogenic Differentiation of Rat Bone Marrow Stromal Cells

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