Succinate as a Growth Factor for
            <i>Bacteroides melaninogenicus</i>

Lev, M.; Keudell, K. C.; Milford, Albert F.

doi:10.1128/jb.108.1.175-178.1971

Cited by 105 publications

(27 citation statements)

References 11 publications

(7 reference statements)

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“…It is also well known that hemin is an essential nutrient for suspected periodonto-pathic pathogens sueh as B. gingivalis and B. intermedius (28). Although the requirement for hemin by these microorganisms can be overcome by succinate (16), usually a very high concentration of the latter is necessary before the effect can be demonstrated. Also it is possible that succinate is simply playing the role of prime preeursor substance for heme biosynthesis (25) by these bacteria.…”

Section: Discussionmentioning

confidence: 99%

Effect of hemoglobin and of ferric ammonium citrate on the virulence of periodontopathic bacteria

Mukherjee

Murphy

Wawszkiewcz

1988

Oral Microbiology and Immunology

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The effect of the iron‐containing substances hemoglobin (Hb) and ferric ammonium citrate (FAC) on the virulence of a strain of Streptococcus sanguis, Actinomyces viscosus, Actinobacillus actinomycetemcomitans, and 2 strains of Bacteroides gingivalis was studied in a guinea‐pig model. The results showed that the addition of Hb or FAC had no effect on the virulence of S. sanguis. However, the addition of Hb but not FAC had an enhancing effect on the virulence of A. viscosus and B. gingivalis. The addition of FAC but not Hb enhanced the virulence of A. actinomycetemcomitans. This study, suggests that the virulence of periodontopathic bacteria could be dependent upon the nature of the iron compound in the host medium.

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Section: Discussionmentioning

confidence: 99%

Effect of hemoglobin and of ferric ammonium citrate on the virulence of periodontopathic bacteria

Mukherjee

Murphy

Wawszkiewcz

1988

Oral Microbiology and Immunology

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“…Anaerobic bacteria were found infrequently, probably because of the use of techniques that did not support the preservation and isolation of anaerobes. The rapid development of anaerobic techniques in the last 3 decades and the increased knowledge about the growth requirements of anaerobic bacteria have led to considerable changes in our understanding of these infections (4)(5)(6)(7)(8)(9)(10). Many infeetions that were previously thought to be caused by aerobic or facultative bacteria are now known to be mixed anaerobic infections (11)(12)(13)(14)(15).…”

Section: Review Of the Literature Historymentioning

confidence: 99%

Bacteroides spp. in dental root canal infections

Haapasalo

1989

Dental Traumatology

107

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A summary of a series of bacteriological studies of endodontic infections is presented in this article. The bacteriology of 62 root canal infections was studied with special attention focused on the occurrence, role and taxonomy of Bacteroides spp. All infections except one were mixed infections dominated usually by anaerobic bacteria. Four to 6 different species were present in most canals. Species of the genus Bacteroides were found more frequently than species of any other genus. Seventy-eight Bacteroides strains were isolated from 45 canals. B. buccae, B. intermedius, B. denticola, B. oris, B. oralis, and B. gingivalis were the most common Bacteroides spp. At the beginning of the treatment 35 of 62 teeth caused acute symptoms. The results indicated that symptoms were a result of the synergistic action of the mixed anaerobic flora. The presence of B. gingivalis, B. endodontalis, and B. buccae was more often related to acute cases than other Bacteroides spp. Black-pigmented Bacteroides and a new Bacteroides-like organism, Mitsuokella dentalis, seemed to increase the probability that acute symptoms would persist one week after the beginning of the treatment. However, the treatment result assessed after 4 weeks and after 1 year was not affected by the composition of the mixed anaerobic flora. Calcium hydroxide was the only canal disinfectant used. Its efficacy was proved by a bacteriological sample at the second appointment in 10 cases. All teeth were asymptomatic at the third appointment. The susceptibility of the isolated Bacteroides strains to penicillin G was also studied. Only 2 B. buccae strains and 2 B. denticola strains were resistant at a concentration of 2.4 micrograms/ml. The patients were randomly divided into 3 groups which received 1) no antibiotics, 2) penicillin V (650 mg x 3) for 7 days, or 3) for 12 weeks. There was no difference between the 3 groups in the healing of the periapical lesion after one year. All patients attended the 1-year control. Fifty cases showed complete healing, partial healing was obtained in 11 cases and in 1 case no healing was observed.

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“…Various hypotheses have been proposed to explain such microbial synergy. It may be due to protection from phagocytosis and intracellular killing (16), production of essential growth factors (17), or lowering of oxidation-reduction potentials in ho.st tissue (18). Our data demonstrate the presence of beta-lactamaseproducing organisms in 80% of NI lesions.…”

Section: Discussionmentioning

confidence: 68%

Microbiology of Nonbullous Impetigo

Brook

Frazier

Yeager

1997

Pediatric Dermatology

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Our objective was to establish the aerobic and anaerobic microbiology of nonbullous impetigo (NI) in children. We used a retrospective review of clinical microbiology laboratory and patients' records. Specimens were obtained from 40 patients with NI lesions and showed bacterial growth. Aerobic or facultative anaerobic bacteria only were present in 24 patients (60%), strict anaerobic bacteria only in 5 patients (12.5%), and mixed anaerobic-aerobic flora was present in 11 patients (27.5%). Sixty-four isolates were recovered (1.6 per specimen): 43 aerobic or facultative, and 21 anaerobic. The predominant aerobic and facultative bacteria were Staphylococcus aureus (29 isolates), Group A beta hemolytic streptococcus (GABHS) (13 isolates), and Escherichia coli (1 isolate). The predominant anaerobes were Peptostreptococcus spp. (12), pigmented Prevotella spp. (5), Fusobacterium spp. (2), and Bacteroides fragilis (1). Single bacterial isolates were recovered in 17 patients (42.5%), 13 of which were S. aureus. S. aureus alone or mixed with GABHS or Peptostreptococcus spp. were isolated from all body sites. Mixed flora of Peptostreptococcus spp. with Prevotella spp. or Fusobacterium spp. was mostly found in infections of the head and neck, while E. coli mixed with B. fragilis and Peptostreptococcus spp. were isolated from one infection of the buttocks area. Thirty-three organisms isolated from 32 patients (80%) produced the enzyme beta-lactamase. This study demonstrates the polymicrobial aerobic-anaerobic microbiology of NI lesions.

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Succinate as a Growth Factor for Bacteroides melaninogenicus

Cited by 105 publications

References 11 publications

Effect of hemoglobin and of ferric ammonium citrate on the virulence of periodontopathic bacteria

Effect of hemoglobin and of ferric ammonium citrate on the virulence of periodontopathic bacteria

Bacteroides spp. in dental root canal infections

Microbiology of Nonbullous Impetigo

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