Succinate and succinate dehydrogenase of mononuclear blood leukocytes as markers of adaptation of mitochondria to hypoxia in patients with exacerbation of chronic obstructive pulmonary disease

Belskikh, Eduard; Uryasiev, Oleg M.; Zvyagina, V I; Faletrova, Svetlana V.

doi:10.23888/pavlovj202028113-20

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Введение. Хроническая обструктивная болезнь легких (ХОБЛ) является одной из ведущих причин заболеваемости и смертности в промышленно развитых и развивающихся странах, занимая 3-е место среди причин ле-тального исхода [1][2][3][4]. Ожидается возрастание влияния ХОБЛ и, следовательно, рост ее экономического бремени [4][5][6].…”

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Chronic Obstructive Pulmonary Disease: Rate of Therapiotic Adherence in Outpatient Practice

Ermachkova,

Smirnova,

Nizov

et al. 2024

Ulyanovsk Medico-biological Journal

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The adherence of a patient with chronic obstructive pulmonary disease (COPD) to treatment is of utmost importance as it prevents the disease progression and the delayed complication development that determine the quality of life and life span. The purpose of the study is to assess the level of adherence for patients with COPD to drug therapy with respiratory drugs, to identify factors influencing the adherence, and study 5-year survival rate based on adherence level. Materials and Methods. The study enrolled 150 patients with COPD (87 men, and 63 women, mean age 58.3±0.86 years). Pulmonary function (FEV1, FVC, FEV1/FVC), severity of respiratory symptoms (mMRS scale, CAT questionnaire), and disease severity were assessed (GOLD, 2022). Adherence to COPD treatment was determined according to the Morisky-Green test (1986). Five-year survival rate of patients was analyzed. Results. Low adherence to treatment in patients with COPD was revealed: 1 month after the initiation or correction of respiratory therapy, only 32 patients (21.3 %) were assessed as adherent, 56 patients (37.3 %) were insufficiently adherent, and 62 patients (41.3 %) were non-adherent to treatment. Adherence to treatment was associated with age, disease severity, severity of respiratory symptoms, FEV1 and did not depend on gender. In five years, survival rate in the group of non-adherent patients (89.5 %) and insufficiently adherent patients (80.4 %) was significantly higher than in the group of adherent one (61.9 %). It is associated with a more severe status of patients who are adherent to therapy. Conclusion. The authors identified an insufficient adherence level in patients with COPD. Elderly patients with a more severe course of the disease, low FEV1 levels, and severe exacerbations are more adherent to respiratory drug therapy. Worse five-year survival rates were observed in the group of patients who were adherent to therapy. It was associated with more severe clinical status, age and comorbidity.

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Chronic Obstructive Pulmonary Disease: Rate of Therapiotic Adherence in Outpatient Practice

Ermachkova,

Smirnova,

Nizov

et al. 2024

Ulyanovsk Medico-biological Journal

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Characteristics of Adaptive Capabilities of Frequently Ill Primary School-Aged Children

Smirnova,

Ovcharenko,

Kasparov

et al. 2023

I.P. Pavlov Russian Medical Biological Herald

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INTRODUCTION: In childhood, the immune system is actively formed, among other things, through the contact with viral and bacterial pathogens. Children over 5 years who suffer from acute respiratory diseases more than 4 times a year, are referred to the group of frequently ill children (FIC) requiring increased attention of doctors. AIM: To identify peculiarities of the autonomic regulation, metabolic, regulatory parameters of immune system cells in FIC of the primary school age. MATERIALS AND METHODS: The study involved 114 children aged 711 years. On the basis of the data of the card of childs individual development, a group of FIC was identified with recurrence rate of acute respiratory diseases more than 4 times a year (n = 28). A control group included episodically ill children (13 times a year, n = 86). The condition of the autonomic system of a child was evaluated by the data of heart rate variability using ORTO Valeo hardwaresoftware complex. The content of serotonin and catecholamines in blood lymphocytes was determined using luminescent histochemical method. Activity of succinate dehydrogenase and acid phosphatase were evaluated by cytochemical methods. RESULTS: The study of regulatory-metabolic parameters of immune cells in the group pf FIC showed reduced activity of succinate dehydrogenase (р 0.01) and reduced content of serotonin (р 0.01), and high activity of acid phosphatase (р 0.05) and catecholamines (р 0.001) in comparison with the control group. The analysis of parameters of autonomic regulation in FIC group showed predominance of parameters characterizing the sympathetic division of the autonomic nervous system and reduction of parameters characterizing the activity of the parasympathetic division (р 0.05). CONCLUSION: The results evidence a sharp imbalance between metabolic and catabolic processes in the immune system of FIC of the primary school age with the underlying predominant activity of the sympathetic nervous system. This gives the ground to study the reasonability of administration of medications and physiotherapeutic procedures for correction of the parameters of the autonomic regulation in the inter-recurrence period with the aim of improving the general adaptive capacities of FIC of the primary school age.

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Features of the clinical course of neurodegenerative brain disease caused by mutations in the neurophacitis and succinate dehydrogenase gene: clinical case

Tkachuk,

Astakhova,

Rychkova

et al. 2023

Medicinskij sovet

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Neurodegenerative diseases of the brain pose a serious challenge in diagnosis and treatment. Of particular interest are diseases caused by complex mutations, the clinical picture of which is ambiguous. The article presents a description of a clinical case of a neurodegenerative disease of the brain with symmetrical damage to the cerebellar hemispheres in the projection of the dentate nuclei, in the region of the superior and middle cerebellar peduncles, in the region of the midbrain tegmentum, along the corticospinal tracts, in the subcortical sections of the frontoparietal regions of the brain. It has been shown that these clinical manifestations are caused by the formation of small foci of demyelination in the white matter of the brain. The cause of the disease was revealed to be a deficiency of mitochondrial complex II, nuclear type 4, which is caused by mutations in the NFASC (encoding neurofascin) and SDHB (encoding succinate dehydrogenase) genes. The leading clinical manifestations in this case were motor disorders in the form of persistent bilateral ptosis, external ophthalmoplegia, optic disc atrophy, retinal pigmentary degeneration, subcortical dysarthria, sensorineural hearing loss, and cognitive impairment. However, the clinical picture of this disease developed latently for a long time, which made its diagnosis difficult. The reason for this was a complex genetic defect including mutations in the neurofasciitis and succinate dehydrogenase gene. The paper provides a discussion of currently known effective methods of treating the disease.

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Succinate and succinate dehydrogenase of mononuclear blood leukocytes as markers of adaptation of mitochondria to hypoxia in patients with exacerbation of chronic obstructive pulmonary disease

Cited by 4 publications

References 9 publications

Chronic Obstructive Pulmonary Disease: Rate of Therapiotic Adherence in Outpatient Practice

Chronic Obstructive Pulmonary Disease: Rate of Therapiotic Adherence in Outpatient Practice

Characteristics of Adaptive Capabilities of Frequently Ill Primary School-Aged Children

Features of the clinical course of neurodegenerative brain disease caused by mutations in the neurophacitis and succinate dehydrogenase gene: clinical case

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