Successful use of maintenance rTMS for 8 months in a patient with antipsychotic-refractory auditory hallucinations

“…However, it is now increasingly becoming evident that significant proportions (40-70%) of TRS patients have suboptimal response to clozapine (1,2). Owing to this, many patients with TRS do require augmentation of clozapine with other antipsychotics (3), other medications (3), transcranial magnetic stimulation (4)(5)(6)(7)(8) and transcranial direct-current stimulation (9).…”

Section: Introductionmentioning

confidence: 99%

Combined use of clozapine and ECT: a review

Grover

Hazari

Kate

2015

Acta Neuropsychiatr.

View full text Add to dashboard Cite

show abstract

“…Hoffman et al reported an improvement in auditory hallucination severity in those patients, as rated on a visual analogue scale (VAS) [8]. Since then, several studies have used rTMS to treat auditory hallucinations in schizophrenic patients, targeting almost exclusively the left temporoparietal cortex, with mixed results [3,4,7,9,10]. The physiological basis of the rTMS-induced beneficial effect on auditory hallucinations is not well understood, but may reflect reduced pyramidal neuron excitability or neuroplasticity changes analogous to those associated with long-term depression [3,4,10].…”

Section: Introductionmentioning

confidence: 99%

Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: a preliminary open-label study

et al. 2011

View full text Add to dashboard Cite

BackgroundSchizophrenia is a chronic and disabling disease that presents with delusions and hallucinations. Auditory hallucinations are usually expressed as voices speaking to or about the patient. Previous studies have examined the effect of repetitive transcranial magnetic stimulation (TMS) over the temporoparietal cortex on auditory hallucinations in schizophrenic patients. Our aim was to explore the potential effect of deep TMS, using the H coil over the same brain region on auditory hallucinations.Patients and methodsEight schizophrenic patients with refractory auditory hallucinations were recruited, mainly from Beer Ya'akov Mental Health Institution (Tel Aviv university, Israel) ambulatory clinics, as well as from other hospitals outpatient populations. Low-frequency deep TMS was applied for 10 min (600 pulses per session) to the left temporoparietal cortex for either 10 or 20 sessions. Deep TMS was applied using Brainsway's H1 coil apparatus. Patients were evaluated using the Auditory Hallucinations Rating Scale (AHRS) as well as the Scale for the Assessment of Positive Symptoms scores (SAPS), Clinical Global Impressions (CGI) scale, and the Scale for Assessment of Negative Symptoms (SANS).ResultsThis preliminary study demonstrated a significant improvement in AHRS score (an average reduction of 31.7% ± 32.2%) and to a lesser extent improvement in SAPS results (an average reduction of 16.5% ± 20.3%).ConclusionsIn this study, we have demonstrated the potential of deep TMS treatment over the temporoparietal cortex as an add-on treatment for chronic auditory hallucinations in schizophrenic patients. Larger samples in a double-blind sham-controlled design are now being preformed to evaluate the effectiveness of deep TMS treatment for auditory hallucinations.Trial registrationThis trial is registered with clinicaltrials.gov (identifier: NCT00564096).

show abstract

Successful use of maintenance rTMS for 8 months in a patient with antipsychotic-refractory auditory hallucinations

Cited by 34 publications

References 6 publications

The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements

The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements

Combined use of clozapine and ECT: a review

Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: a preliminary open-label study

Contact Info

Product

Resources

About