Successful Use of Bortezomib in an Adolescent with Refractory TTP
Junaid Ahmad Wali,
Brian M. Quigley,
Beverly Schaefer
Abstract:With increasing early and upfront use of rituximab and caplacizumab in the modern management of immune-mediated thrombotic thrombocytopenic purpura (iTTP), the risk of refractory disease is expected to decline. However, despite the use of adequate initial therapy, a small subset of patients develop a refractory disease which is difficult to manage. Bortezomib has come to be known as a safe and effective treatment option for refractory iTTP, but its use in children is limited. Here, we describe the case of an a… Show more
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