Successful Tumour Immunotherapy With Cimetidine in Mice

Osband, MichaelE.; Shen, Yuan-Jin; Shlesinger, Menachem; Brown, Anne; Hamilton, Douglas A.; Cohen, Ellen B.; Lavin, Philip T.; McCaffrey, Ronald P.

doi:10.1016/s0140-6736(81)91554-3

Cited by 148 publications

(41 citation statements)

References 13 publications

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“…Cimetidine has demonstrated immunomodulatory effects in a number of studies (32)(33)(34)(35)(36), while histamine has been shown to have immunosuppressive effects (37,38). These results suggest that the effect of cimetidine on immunity is mediated by blocking the immunosuppressive effect of histamine via the H 2 receptor.…”

Section: Discussionmentioning

confidence: 99%

Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats

Furuta

Sato²,

Miyake³

et al. 2008

Oncol Rep

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Abstract. Cimetidine is known to have an anti-tumor effect on certain types of malignancies, though on hepatocellular carcinomas (HCCs), its effect remains unclear. We studied the anti-tumor effects of cimetidine on chemically-induced HCCs in rats. Four-week-old male Wistar rats (n=105) were divided into 4 groups. Those in groups A and B were administered diethylnitrosamine (DEN) intraperitoneally at 100 mg/kg body weight every week for 6 weeks, during which rats in group A were given tap water and those in group B received cimetidine (100 mg/kg/day) in their drinking water. Rats in groups C and D were administered saline instead of DEN and given tap water with 100 mg/kg/day of cimetidine, respectively. The animals were sacrificed at 7, 12, 22 and 32 weeks after the first administration of drugs and examined. Liver nodules were observed only in groups A and B, with the number of nodules, maximum diameter of the largest nodule, and liver weight significantly lower in group B. Immunohistochemistry findings showed that glutathione S-transferase placental-positive preneoplastic foci were significantly decreased in group B. Cimetidine treatment decreased the number of proliferating cell nuclear antigen-positive hepatocytes and tended to enhance natural killer (NK) cell activity in splenic lymphocytes. In addition, flow cytometry revealed that the proportion of NK cells among total splenic lympocytes was not affected by cimetidine treatment. Our results showed that cimetidine has an inhibiting effect on hepatocarcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Anti-tumor effects of cimetidine on hepatocellular carcinomas in diethylnitrosamine-treated rats

Furuta

Sato²,

Miyake³

et al. 2008

Oncol Rep

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show abstract

“…An accumulating body of evidence suggests that this drug may improve the survival of patients with different malignancies, and its antitumor effect is mediated at least in part by immune mechanisms. In particular, cimetidine-mediated immunomodulation is based on the the enhancement of antigen-presenting DC activity, 113 inhibition of suppressor T lymphocyte activity 114 and MDSC activity, 115 stimulation of NK cell activity 116 and increase in IL-2 production in helper T lymphocytes. 117 Another H2-antagonist famotidine has been found to stimulate IL-2-driven LAK activity beneficial for the treatment of renal cancer.…”

Section: Inhibitors Of Indoleamine 23-dioxygenase (Ido)mentioning

confidence: 99%

Clinically feasible approaches to potentiating cancer cell-based immunotherapies

Селедцов

Гончаров

Селедцова

2015

Human Vaccines & Immunotherapeutics

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“…H istamine H 2 receptor blockers have been shown to slow down metastatic development and prolong survival in tumor-bearing mice by enhancing the immune response (1,2). Studies have also indicated that H 2 antagonists improve survival in patients with colorectal cancer when given preoperatively or as postoperative adjuvant therapy (3 -6).…”

Section: Original Articlementioning

confidence: 99%