Successful Triple Combination Therapy of Disseminated Absidia corymbifera Infection in an Adolescent With Osteosarcoma

Roux, Bénédicte Gaillard-Le; Méchinaud, Françoise; Gay-Andrieu, Françoise; Lortholary, Olivier; Dannaoui, Éric; Hoinard, Damien; Corradini, Nadège

doi:10.1097/mph.0b013e3181ca0dcf

Cited by 22 publications

(17 citation statements)

References 19 publications

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“…Recurrence and metastasis of the osteosarcoma usually occur at 1-3 years after surgery [18]. In this study, we compared the local recurrence rates and long-term survival rates after application of the 3 surgical methods, and we found that all 3 of these surgical modalities had a certain recurrence and lung metastasis rate.…”

Section: Discussionmentioning

confidence: 98%

Selection of Surgical Methods in the Treatment of Upper Tibia Osteosarcoma and Prognostic Analysis

et al. 2017

Oncol Res Treat

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Background: We aimed to explore the clinical effects and prognosis of different surgical methods in upper tibia osteosarcoma. Methods: Among 112 patients with proximal upper tibia osteosarcoma, 40 patients were treated with amputation, 20 patients were treated with massive osteoarticular allograft, and the remaining 52 cases were treated with tumor resection and artificial joint replacement. Results: Recurrence was observed in 2 cases (5%) in the amputation group, in 6 cases (30%) in the massive osteoarticular allograft group, and in 6 cases (12%) in the tumor resection and artificial joint replacement group (P = 0.021). The lung metastasis rates were 40% in the amputation group, 40% in the massive osteoarticular allograft group, and 38% in the tumor resection and artificial joint replacement group (P = 0.986). The survival rates at 1, 3, and 5 years were 95%, 75%, and 45%, respectively, in the amputation group, 95%, 75%, and 35%, respectively, in the massive osteoarticular allograft group, and 92.3%, 78.8%, and 53.8%, respectively, in the tumor resection and artificial joint replacement group (P > 0.05). Conclusions: The selection of the optimal surgical method for upper tibia osteosarcoma should be made according to the individual circumstances of the patient. Our study has significance for reducing the incidence of surgical complications and improving the quality of postoperative life.

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Section: Discussionmentioning

confidence: 98%

Selection of Surgical Methods in the Treatment of Upper Tibia Osteosarcoma and Prognostic Analysis

et al. 2017

Oncol Res Treat

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“…Fourteen of the sixteen cases where PCZ was used alone were intolerant of or refractory to AmB. Two patients received PCZ with L-AmB and CAS [65,74].…”

Section: Case Seriesmentioning

confidence: 97%

Posaconazole for the treatment of mucormycosis

Enoch

Aliyu

Sule

et al. 2011

International Journal of Antimicrobial Agents

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“…14 Successful triple combination therapy with systemic high doses of liposomal amphotericin B, posaconazole, and caspofungin have also been shown to cure local infection and control systemic lesions in an immunocompromised patient with mucormycosis. 15 Apart from early diagnosis and prompt treatment, correction of any reversible predisposing factors is also an important part of patient management.…”

Section: Case Reportmentioning

confidence: 99%

Intraabdominal Mass as Presentation of Colonic Mucormycosis in a Child With Acute Lymphoblastic Leukemia

Lin

Chou²,

Shen³

et al. 2011

Journal of Pediatric Hematology/Oncology

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Gastrointestinal mucormycosis with clinical presentation as an abdominal mass has been rarely reported in the current literature. In this observation, We report an unusual case of a child with acute lymphoblastic leukemia and neutropenic fever. During hospitalization, increasing abdominal pain and distension occurred, and initially treatments with broad-spectrum antibiotics were administered. However, the symptoms/signs progressed with the development of peritonitis and a palpated mass over the right lower quarter of the abdomen. Imaging studies showed ascending colon perforation with abscess formation. Right hemicolectomy was performed and colonic mucormycosis was confirmed on histologic examination and ascitic fluid culture. Immediately, intravenous liposomal amphotericin B was administered but the clinical condition rapidly deteriorated and the patient expired despite treatment.

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Successful Triple Combination Therapy of Disseminated Absidia corymbifera Infection in an Adolescent With Osteosarcoma

Cited by 22 publications

References 19 publications

Selection of Surgical Methods in the Treatment of Upper Tibia Osteosarcoma and Prognostic Analysis

Selection of Surgical Methods in the Treatment of Upper Tibia Osteosarcoma and Prognostic Analysis

Posaconazole for the treatment of mucormycosis

Intraabdominal Mass as Presentation of Colonic Mucormycosis in a Child With Acute Lymphoblastic Leukemia

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