Successful Trial of Amantadine Hydrochloride for Two Patients with Alternating Hemiplegia of Childhood

Sone, Keiko; Oguni, Hirokazu; Katsumori, Hiroshi; Funatsuka, Makoto; Tanaka, T.; Ōsawa, Makiko

doi:10.1055/s-2000-12945

Cited by 12 publications

(4 citation statements)

References 7 publications

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“…Korinthenberg reported a patient who was resistant to flunarizine responded to memantine [10]. Sone reported the use of amantadine in two patients with AHC [11]. Our 4 patients who were resistant to the above effective agents were given topiramate because of their association with epilepsy and/or migraine.…”

Section: Discussionmentioning

confidence: 86%

Topiramate: A new Agent for Patients with Alternating Hemiplegia of Childhood

Jiang

Chi²,

Ma³

et al. 2006

Neuropediatrics

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Alternating hemiplegia of childhood is a rare syndrome characterized by the onset, before 18 months of age, of frequent attacks of alternating paralysis. Here we report the efficacy of topiramate in four patients with alternating hemiplegia of childhood (AHC) that did not respond to flunarizine, as well as in two newly diagnosed patients. Following treatment with topiramate, the frequency and duration of hemiplegic attacks significantly improved in all patients. Additional symptoms such as seizures, migraine, involuntary movements, autonomic symptoms, and impaired mental development also improved. Topiramate is worth trying when treating patients with AHC as a first trial, or a substitute for flunarizine once the latter agent loses effect.

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Section: Discussionmentioning

confidence: 86%

Topiramate: A new Agent for Patients with Alternating Hemiplegia of Childhood

Jiang

Chi²,

Ma³

et al. 2006

Neuropediatrics

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“…We have reviewed the reports of drug prophylaxis. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, flunarizine, a drug with blocking effects on calcium channels, has been used widely despite it being agreed that it rarely stops attacks. In a review of 20 reports of 230 patients treated with flunarizine, more than 50% of the patients reported reduced duration and severity of attacks and 25% reported a reduced frequency.…”

Section: Prophylaxis For Episode Of Ahcmentioning

confidence: 99%

The treatment and management of alternating hemiplegia of childhood

Neville

Ninan

2007

Develop Med Child Neuro

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Alternating hemiplegia of childhood has many factors that make it difficult to manage. These include its rarity of about one case per million, the variability of the manifestations, with seven characteristic features, and the potential for disabilities and acute, often severe, episodes in a disease that is of uncertain cause and for which treatment evidence is sparse. An integrated multidisciplinary team and emergency availability are key medical requirements, as well as an educational setting that understands the variations in performance that occur. The mainstays of treatment have been flunarizine, antiepilepsy drugs for the 50% of patients with epilepsy, attempts to avoid trigger situations, and the rapid encouragement of sleep when attacks begin. The diagnostic and management predicament of child, parent, and paediatrician in complex rare disorders are well illustrated by this condition.

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“…It was also hypothesised that glutamate and N‐methyl‐D‐aspartate receptors are involved in inducing alternating hemiplegic attacks. Clinically available non‐competitive N‐methyl‐D‐aspartate receptor antagonists like amantadine and its derivative memantine can be used as an alternative agent in add‐on therapy 12,13 . Two of the three patients that we had put on amantadine were admitted with status epilepticus.…”

Section: Discussionmentioning

confidence: 99%