Successful treatment with Yi-Gan San for rapid eye movement sleep behavior disorder

Shinno, Hideto; Kamei, Masahito; Nakamura, Yu; Inami, Yasushi; Horiguchi, Jun

doi:10.1016/j.pnpbp.2008.06.015

Cited by 46 publications

(28 citation statements)

References 11 publications

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“…One good example of Ibyodochi is YKS, a single prescription that is reported to be effective in treating many different diseases such as dementia,1–14 sleep disorders,15,16 tardive dyskinesia,17 borderline personality disorder,18 and schizophrenia-related diseases 19,20. On the other hand, different herbal formulas may also be used to treat the same disease (called “Dobyoichi” in Kampo).…”

Section: Kampo Medicinementioning

confidence: 99%

“…In non-dementia diseases, YKS has been reported to reduce visual hallucinations due to vision loss in patients with Charles Bonnet syndrome 28. There are also reports on the successful treatment of sleep disorders (three cases of rapid eye movement sleep behavior disorder15 and three cases of restless leg syndrome),16 post-stroke emotional incontinence (uncontrollable episodes of crying or laughing in two cases),29 and nocturnal eating/drinking syndrome accompanied by restless leg syndrome and schizophrenia in one case 30. YKS is thus widely used for a variety of diseases in Japan.…”

Section: Case Reportsmentioning

confidence: 99%

“…YKS has attracted attention in the field of psychiatry due to reports of its efficacy in patients with dementia 1–14. In addition, therapeutic effects of YKS have been reported in the treatment of sleep disorders,15,16 tardive dyskinesia,17 borderline personality disorder,18 and schizophrenia-related diseases 19,20. The claim of YKS’s effectiveness for such a wide variety of indications may produce skepticism toward Kampo medicine and possibly weaken its reputation, especially if YKS is ineffective or harmful because of improper usage.…”

Section: Introductionmentioning

confidence: 99%

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Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions

Okamoto¹,

Iyo²,

Ueda³

et al. 2014

NDT

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Japanese traditional herbal medicine (Kampo) has its origins in traditional Chinese medicine (TCM). It was introduced to Japan in the middle of the sixth century and has evolved over the past 1,400 years after combining with Japan’s original folk remedies. While it retains some similarities to TCM, Kampo has evolved in Japan, resulting in a system of medicine that has many differences from TCM. Kampo medicine is considered to be very safe; in Japan, Kampo herbal formulas are manufactured by licensed pharmaceutical companies, prescribed by Western-trained medical doctors (usually as a freeze-dried extract), and have quality control standards similar to those of prescription drugs. The present study examined Yokukan-san (Yi-Gan San in TCM), a Kampo formula that has been used empirically in Japan for more than 400 years. Accumulating clinical trials have demonstrated Yokukan-san’s efficacy in treating patients with behavioral and psychological symptoms of dementia, which has resulted in the Japanese Society of Neurology listing it in the Japanese Guidelines for the Management of Dementia 2010. Efficacy in other diseases and conditions, such as sleep disorders, tardive dyskinesia, aggression, and impulsivity has also been reported. This article reviews both clinical and basic studies of Yokukan-san, with the goal of clarifying its clinical indications.

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Section: Kampo Medicinementioning

confidence: 99%

Section: Case Reportsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions

Okamoto¹,

Iyo²,

Ueda³

et al. 2014

NDT

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show abstract

“…Melatonin (3-12 mg) at bedtime has been shown to ameliorate RBD [111,112]. Administration of Yi-Gan San, an herbal medication, at 2.5 g three times a day, alone or in conjunction with 0.25 mg clonazepam, may also be effective [113]. Some patients may respond to 1 evening or bedtime dose of 2.5g.…”

Section: Rapid Eye Movement Sleep Behavior Disordermentioning

confidence: 99%

Sleep Disturbances in Patients with Parkinson’s Disease

Suzuki¹,

Miyamoto²,

Miyamoto³

et al. 2014

A Synopsis of Parkinson's Disease

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“…Melatonin (3-12 mg) at bedtime has been shown to ameliorate RBD (Aurora et al, 2010). Administration of 2.5 g of Yi-Gan San, an herbal medication, three times a day, alone or in conjunction with 0.25 mg clonazepam, has also been reported to be effective in the treatment of RBD (Shinno et al, 2008).…”

Section: Rem Sleep Behavior Disorder (Rbd)mentioning

confidence: 99%