Successful treatment with stereotactic radiosurgery for brain metastases of endometrial carcinoma: A case report and review of the literature

Shiohara, Shigeki; Ohara, Masahiro; Itoh, Kazuko; Shiozawa, Tanri; Konishi, Ikuo

doi:10.1046/j.1525-1438.2003.13017.x

Cited by 23 publications

(21 citation statements)

References 37 publications

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“…87,88 In addition, for brain metastases, stereotactic radiotherapy showed to be a good alternative for whole brain radiotherapy, with less risk of neurocognitive damage. 89,90 CONCLUSIONS Our efforts should focus on defining the optimal treatment of primary endometrial cancer to prevent recurrences in the first Table 1, recommendations for the management of patients with recurrent endometrial cancer are proposed. These recommendations are based on the available evidence in the literature, which consists in most cases only of level of evidence IV.…”

Section: Distant Recurrencementioning

confidence: 99%

Management of Recurrent Endometrioid Endometrial Carcinoma: An Overview

Wijk

Burg

Burger

et al. 2009

Int J Gynecol Cancer

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In this paper, an overview of the literature on the management of recurrent endometrial cancer is presented, focusing on patients with histopathologic endometrioid type of tumors. The different treatment modalities are described, and a management recommendation scheme is presented. Indications for surgical treatment depend on resectability, site and size of the tumor, and performance status of the patient. Indications for radiotherapy depend on the site of the recurrence and also on the initial therapy received. When considering systemic treatment for patients with recurrent endometrial cancer, it is important to take into account the general health status and condition of the patient as well as which prior therapy the patient has received. The treatments of choice for patients with hormone-sensitive tumors (positive receptor levels, low-grade tumors, and long disease-free interval) are progestagens as first-line treatment and tamoxifen as second-line treatment. Patients with high-grade tumors, negative hormone receptor levels, and short treatment-free interval are best treated with chemotherapy. Paclitaxel, doxorubicin, and cisplatin are the most active combination therapy for these patients but with significant toxicity. In phase II studies, the combination therapy with paclitaxel and carboplatin seems to be as effective but less toxic and can be administered in outpatient clinic. The literature on the management of patients with recurrent endometrial cancer is discussed in detail. The different sites of recurrent disease (ie, local, regional, and/or distant) are evaluated separately; management recommendations are proposed, and alternative approaches are given.

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Section: Distant Recurrencementioning

confidence: 99%

Management of Recurrent Endometrioid Endometrial Carcinoma: An Overview

Wijk

Burg

Burger

et al. 2009

Int J Gynecol Cancer

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“…Factors examined for their possible association with CNS metastasis from endometrial cancer have included unfavorable clinical disease stage or high-grade tumor (109,110) , lymph node involvement (111) , deep myometrial invasion (108) , cervical involvement (108,110) , and lymphovascular space invasion (109,110) . Cases in which the tumor is high grade and lymphovascular space invasion and deep myometrial invasion are present may be more prone to metastasize earlier in the course of the disease (108) .…”

Section: Cns Metastasesmentioning

confidence: 99%

“…This review revealed 16 patients from nine published studies who underwent surgery for brain metastases from endometrial cancer (107)(108)(109)(110)(112)(113)(114)(115)(116) (Table 7). Six of seven patients with stage IV disease had brain metastasis at diagnosis, and the seventh developed brain metastasis 3 months after bone metastasis at primary diagnosis.…”

Section: Cns Metastasesmentioning

confidence: 99%

“…Six of seven patients with stage IV disease had brain metastasis at diagnosis, and the seventh developed brain metastasis 3 months after bone metastasis at primary diagnosis. Five patients presented with neurologic manifestations that resulted in diagnosis of primary tumor upon further investigations (107,108,110) . The characteristic features of the diseases or risk factors in these patients are summarized in Table 8.…”

Section: Cns Metastasesmentioning

confidence: 99%

“…The seemingly better survival among the seven patients with stage IV disease undoubtedly Alive with disease Shiohara (110) Surgery in metastatic gynecological cancer 417 reflected the inclusion of two unusual cases. In one of these cases, the patient had three rounds of surgery or stereotactic radiosurgery plus chemotherapy for recurrent brain lesions and survived for more than 3 years (110) ; in the other case, a patient survived for 171 months despite having had an incomplete resection and brain lesions that persisted radiologically after chemotherapy and hormonal treatment (107) . With the small number of patients reported, it is hard to draw the conclusions regarding factors influencing survival.…”

Section: Cns Metastasesmentioning

confidence: 99%

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Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review

TANGJITGAMOL,

LEVENBACK,

BELLER

et al. 2004

Int J Gynecol Cancer

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Many reports of ovarian, cervical, and uterine cancers metastatic to lung, liver, and brain have been published. A fewer number of them focused on the surgical treatment for these patients. We reviewed the published literature, regarding surgical management of metastatic disease in patients with gynecological cancer. Some prognostic factors in the patients with metastatic lesions from these three different cancers were found in common. Favorable prognostic factors for a prolonged survival were good performance status of the patients, long disease-free interval, absence of other systemic disease, and the resectability, preferably with a clear margin. These factors should be considered as the criteria for surgery. In well-selected patients, survival could be extended from the surgical procedure with minimal complications. Other types of treatment such as radiation therapy or chemotherapy could also be given in conjunction with surgery, depending on tumor type and disease status of the primary cancer, other systemic diseases, and residual metastatic lesions after surgery.

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Management of brain metastases from ovarian and endometrial carcinoma with stereotactic radiosurgery

Monaco

Kondziolka

Mongia

et al. 2008

Cancer

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BACKGROUND Metastases to the brain from ovarian and endometrial carcinoma are uncommon and to the authors' knowledge consensus regarding optimal management is lacking. Stereotactic radiosurgery (SRS) has proven useful for the treatment of many benign and malignant brain tumors. In the current study, the authors evaluated outcomes after SRS in patients with ovarian and endometrial carcinoma. METHODS Twenty‐seven patients with brain metastases underwent gamma–knife SRS. Six patients had endometrial carcinoma, whereas 21 patients had ovarian carcinoma. Eighteen patients also received whole–brain radiotherapy. A total of 68 tumors were treated with gamma–knife SRS. RESULTS At the time of last follow–up, 1 patient was still alive and 26 had died. The median survival was 7 months after the initial diagnosis of brain metastasis and 5 months after SRS. The 1‐year survival rate after radiosurgery was 15% and that from the diagnosis of brain metastases was 22%. On final imaging, all tumors were controlled without further growth. Two patients (7.4%) developed new or progressive neurologic deficits after SRS. CONCLUSIONS SRS is an acceptable choice for the treatment of brain metastases resulting from ovarian and endometrial carcinoma, and provides local tumor control with limited morbidity. Careful patient selection is warranted in the setting of patients with uncontrolled systemic disease in whom a limited survival benefit is expected. Cancer 2008. © 2008 American Cancer Society.

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Successful treatment with stereotactic radiosurgery for brain metastases of endometrial carcinoma: A case report and review of the literature

Cited by 23 publications

References 37 publications

Management of Recurrent Endometrioid Endometrial Carcinoma: An Overview

Management of Recurrent Endometrioid Endometrial Carcinoma: An Overview

Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review

Management of brain metastases from ovarian and endometrial carcinoma with stereotactic radiosurgery

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