Successful Treatment With Meloxicam, a Cyclooxygenase-2 Inhibitor, of Patients With Extra-Abdominal Desmoid Tumors: A Pilot Study

Nishida, Yoshihiro; Tsukushi, Satoshi; Shido, Yoji; Wasa, Junji; Ishiguro, Naoki; Yamada, Yoshihisa

doi:10.1200/jco.2009.25.5950

Cited by 59 publications

(58 citation statements)

References 6 publications

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“…with or without radiotherapy) and different surgical margin statuses [microscopically negative (R0) or positive (R1) margins] (10)(11)(12). In previous studies by the present authors, patients with extraperitoneal desmoid tumors were prospectively and consecutively treated with meloxicam, a cyclooxygenase-2 (COX-2) inhibitor (13,14), and a significant predictive value of CTNNB1 for this conservative treatment was demonstrated (15).…”

Section: Introductionmentioning

confidence: 99%

Simple resection of truncal desmoid tumors: A case series

et al. 2016

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Abstract. Desmoid tumors of the extra-abdominal and abdominal wall have been associated with morbidity due to the aggressive nature of the surgery and high recurrence rates. Surgery that does not cause functional impairment is desired for patients with desmoid tumors. In the present study, among patients with desmoid tumors who were prospectively and consecutively treated with identical conservative treatment with meloxicam, a selected patients of patients were treated with less invasive surgery than wide-resection. Out of 60 patients pathologically diagnosed with desmoid tumors, 9 patients with tumors refractory to conservative treatment and 4 patients who refused to receive this type of treatment were treated with planned simple resection. Subsequently, the clinical outcome of the patients and the mutational status of the catenin β-1 (CTNNB1) gene in the tumors were analyzed. The mean age of the 13 patients that underwent planned simple resection was 39 years, and the tumors were located in the abdominal wall in 6 cases, the chest wall in 4 cases and the neck in 3 cases. All excised specimens were evaluated and positive microscopic margins were identified; however, during the mean follow-up period of 30 months, 12/13 cases, 7 of which had T41A mutations and 5 of which had no mutations (wild-type), did not develop recurrence. Only 1 initial case with an S45F mutation in the CTNNB1 gene developed recurrence. The results of the present prospectively treated with simple resection and retrospectively analyzed study suggest that planned simple resection could serve as a therapeutic modality for extraperitoneal desmoid tumors, particularly truncal ones with a wild-type or T41A mutational status.

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Section: Introductionmentioning

confidence: 99%

Simple resection of truncal desmoid tumors: A case series

et al. 2016

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“…Some previous reports have shown that COX-2 inhibitors were effective to treat intra-abdominal DF and that COX-2 inhibitors reduce local progression of DF [18,20]. However, to date there have been no reports investigating the role of COX-2 in DF recurrence.…”

Section: Issn 0970-938x Wwwbiomedresinfomentioning

confidence: 91%

“…Biomedical Research 2018; 29 (13): 2718-2721 [18,19]. This strategy enables the identification of patients who remain asymptomatic with stable illness or experience spontaneous regression and protects this cohort from unnecessary treatment.…”

Section: Issn 0970-938x Wwwbiomedresinfomentioning

confidence: 99%

Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature

Hashimoto¹,

Nishimura²,

Oka³

et al. 2018

biomedicalresearch

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Background: Desmoid fibromatosis (DF) is a type of fibrous tumor that rarely metastasizes but often recurs locally. Cyclooxygenase-2 (COX-2) has been shown to be expressed in DF lesions, although its involvement in DF recurrence is unknown. We investigated the association between COX-2 expression and DF recurrence using immunohistochemistry. Patients and methods: Cases of DF treated in our hospital between March 2000 and December 2012 were reviewed. We used immunohistochemistry to identify COX-2 expression in resected specimens from these cases. The relationship between recurrence and age, sex, duration of disease, size of tumor, tumor site, spontaneous pain, inflammation, and COX-2 expression was studied. Results: In the ten included cases (mean age, 55.2 y; 5 male and 5 female patients), we found that COX-2 expression was significantly associated with DF recurrence (p=0.01). Conclusion: Our findings indicate that COX-2 is involved in recurrence of DF.

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“…Radiotherapy was added to the treatment in the present case due to close surgical margins. Non-steroid anti-inflammatory agents (10), and hormonal therapy, also including tamoxifen (11), and imatinib (12), have been recommended in the literature. As the sample from the present case was immunohistochemically stained CD117(+), maintenance imatinib treatment was started upon the completion of radiotherapy, which was consistent with a previous study (12).…”

Section: Discussionmentioning

confidence: 99%

Occurrence of an intrathoracic desmoid tumor following breast cancer treatment: A case report

Değirmencioğlu

Demiray

Yaren

et al. 2015

Molecular and Clinical Oncology

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Abstract. Desmoid tumors are rarely observed tumors that develop from deep muscle and aponeurotic tissues. They are histologically intermediate, and exhibit a local aggressive course. These tumors have been observed in the abdominal region, and are rarely encountered in the thoracic wall. The most effective treatment appears to be surgery. A 59-year-old female patient was admitted with the complaint of right breast pain and a palpable mass. The patient had undergone a modified radical mastectomy surgical procedure of the right breast due to invasive breast carcinoma 10 years before. A mass with a soft tissue density and a size of 44x22 mm was detected in the thoracic computed tomography of the patient, which subsequently resulted in biopsy followed by surgery. As a result of the pathological examination of the mass, the diagnosis was determined as desmoid tumor. Due to the closeness of the tumor to the surgical margin, the patient was administered radiotherapy and maintenance imatinib treatment was started.

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Successful Treatment With Meloxicam, a Cyclooxygenase-2 Inhibitor, of Patients With Extra-Abdominal Desmoid Tumors: A Pilot Study

Cited by 59 publications

References 6 publications

Simple resection of truncal desmoid tumors: A case series

Simple resection of truncal desmoid tumors: A case series

Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature

Occurrence of an intrathoracic desmoid tumor following breast cancer treatment: A case report

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