Successful treatment with laparoscopic surgery and sequential multikinase inhibitor therapy for hepatocellular carcinoma: A case report

Surgery for Hepatocellular Carcinoma With Macroscopic Vascular Invasion in the Era of Modern Molecular Therapy

“…Conversion hepatectomy is one of the essential options for prolonging survival in patients with initially unresectable HCC that has been down-staged to being resectable by conversion therapy (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44). The number of articles on the advantages of conversion surgery after molecular therapy has increased.…”

“…After the initiation of molecular therapy, the number of patients with complete response (CR) by response evaluation criteria in solid tumors (RECIST) and modified RECIST (mRECIST) criteria in diagnostic imaging increased; in contrast, complete remission of HCC is rarely achieved by molecular therapy alone (36). Conversely, many long-term survivors, including those completely cured, have been reported in patients with initially unresectable HCC after molecular therapy followed by conversion surgery (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43). Partial response (PR) or stable disease after molecular therapy is required for patients to undergo conversion surgery, but CR is not always required (31).…”

“…Patients with HCC with MVI are one of the main candidates for such conversion surgery. Data for patients with MVI by HCC undergoing curative conversion surgery are summarized in Table I (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). All patients were male, Table I.…”