Successful Treatment With Hydroxyzine of Acute Exacerbation of Panic Disorder in a Healthy Man

Iskandar, Joseph W.; Griffeth, Benjamin; Rubio-Cespedes, Christian

doi:10.4088/pcc.10l01126

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…However, it has at least two beneficial properties --an effect can be perceived faster than many other oral anxiolytics, and like other antimuscarinic agents it has a desirable risk/benefit profile (i.e., doesn't produce dependency). In addition to treating generalized anxiety disorder, a few case reports suggests it might be beneficial in treating panic disorder [87,88].…”

Section: Muscarinic Receptor Antagonistsmentioning

confidence: 99%

Treating Anxiety with either Beta Blockers or Antiemetic Antimuscarinic Drugs: A Review

Dooley¹

2015

Ment Health Fam Med

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Beta adrenergic receptor antagonists and antiemetic muscarinic receptor antagonists are useful for mental health in primary care and family medicine settings, as they provide favorable risk/benefit profiles, and especially so relative to benzodiazepines. Beta blockers (e.g., propranolol) prescribed off-label have been known for decades to provide some, albeit limited, anxiolytic benefit for patients affected by social anxiety disorder (social phobia), including performance anxiety. Blockage of adrenaline's binding to cardiovascular beta adrenergic receptors inhibits tachycardia, reduces blood pressure, and thus diminishes palpitations in acute anxiety and panic. However, beta blockers are not effective against the psychic (CNS) symptoms, such as anxiousness, fear, and avoidance. Another approach involves antiemetic muscarinic receptor antagonists that are available by prescription (e.g., scopolamine) or over-the-counter (e.g., meclizine) for the treatment of non-cardiovascular symptoms that manifest in anxiety disorders. Antiemetic agents inhibit nausea, vomiting, sweating, and in some instances other psychic (CNS) symptoms. The symptoms affected by antimuscarinic agents represent the "inverse" of the symptoms of acute anxiety affected by beta blockers. Thus, anxiety disorders can be treated by alternative biochemical pathways, as well as by affecting alternative symptoms thereof. The results of human clinical studies are summarized for both classes of anxiolytic agents that display complementary pharmacologic approaches to a diverse array of symptoms.

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Section: Muscarinic Receptor Antagonistsmentioning

confidence: 99%

Treating Anxiety with either Beta Blockers or Antiemetic Antimuscarinic Drugs: A Review

Dooley¹

2015

Ment Health Fam Med

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“…An antihistamine with sedative properties, there is some small support of its use for anxiety, including panic disorder [55]. Despite having FDA approval for use with GAD, empirical evidence of hydroxyzine effectiveness for GAD is mixed [56][57][58].…”

Section: Hydroxyzinementioning

confidence: 99%

Evidence-Based Pharmacotherapies for Panic Disorder

Norrholm¹

2023

The Psychology of Panic

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This chapter presents a review of the primary psychopharmacological interventions for panic disorder and the empirically derived evidence supporting their continued use. Key factors such as dosing, contraindications, safety, tolerability, and polypharmacy are discussed. The chapter will include a currently supported tier structure for pharmacological treatment planning as well as means for how best to tailor regimens to specific patient needs. Comorbidities and practical applications are addressed as well. Lastly, the chapter closes with some emerging pharmacotherapies that show promise but for which empirical evidence supporting their use remains in its infancy.

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Successful Treatment With Hydroxyzine of Acute Exacerbation of Panic Disorder in a Healthy Man

Cited by 2 publications

References 2 publications

Treating Anxiety with either Beta Blockers or Antiemetic Antimuscarinic Drugs: A Review

Treating Anxiety with either Beta Blockers or Antiemetic Antimuscarinic Drugs: A Review

Evidence-Based Pharmacotherapies for Panic Disorder

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