Successful Treatment with Dabrafenib/Trametinib of a Malignantly Transformed and Metastasized BRAF V600E Mutant Pleiomorphic Xanthoastrocytoma: A Case Report and Review of the Literature
Elle Vermeulen,
An-Sofie Vander Mijnsbrugge,
Stefanie Brock
et al.
Abstract:<b><i>Introduction:</i></b> Pleiomorphic xanthoastrocytoma (PXA) is considered a low-grade glioma with a favorable prognosis following surgical resection. We present a case report of a <i>BRAF</i><sup><i>V600E</i></sup> mutant malignantly transformed and disseminated PXA that was successfully treated with BRAF-/MEK-targeted therapy (dabrafenib/trametinib). <b><i>Case Presentation:</i></b> At the age of 16 years, our patient und… Show more
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