Successful treatment to a tretinoin/clindamycin gel in a late onset of nevus comedonicus

Successful treatment of late‐onset nevus comedonicus with Er:YAG laser

“…In 50% of NC cases, the lesions appear shortly after the birth, and in the majority of the cases lesions develop before the age of 10 . It rarely appears in adulthood, only single case reports of development of NC in adulthood have been presented . Large grouped, dilated follicular ostia filled with keratin layers is the majör histopathologic finding of NC …”

“…Although NC is a benign condition, treatment is usually required for aesthetic reasons or in complicated cases (cyst formation, with secondary infection and development of scarring). Several therapies have been reported in the treatment of NC, including keratolytic agents such as salicylic acid and 0.1% retinoic acid, vitamin D derivatives, and 12% ammonium lactate, topical tretinoin/clindamycin, laser (CO2, Erbium Yag, diode laser) therapies, or complete surgical removal. Still there is no generally accepted and effective therapy in NC.…”

“…Nevus comedonicus (NC) is a hamartomatous proliferation of pilosebaceous unit, first described by Kofmann in 1895 . Occurrence of NC during adulthood is rarely reported . Although several therapies have been reported in the literature, treatment of the NC still remains a challenge …”

“…3,[6][7][8] It rarely appears in adulthood, 6 only single case reports of development of NC in adulthood have been presented. 3,4 Large grouped, dilated follicular ostia filled with keratin layers is the majör histopathologic finding of NC. 3 Although NC is a benign condition, treatment is usually required for aesthetic reasons or in complicated cases (cyst formation, with secondary infection and development of scarring).…”