Successful Treatment of White Sponge Nevus with Oral Doxycycline: A Case Report and Review of the Literature

Amores-Martín, Elisabet; Melé‐Ninot, Gemma; Viladomiu, Elena del Alcázar; Fernández‐Figueras, María Teresa

doi:10.1016/j.adengl.2019.10.014

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…Although WSN is prone to recurrence, it is generally considered benign and therefore does not require special treatment for asymptomatic patients. At present, the overall performance of various treatments is not good although some studies have reported certain clinical efficacy after pharmacological treatment with vincristine, chlorhexidine, penicillin, tetracycline, azithromycin, clotrimazole lotion, or local surgical excision ( Table 3 ) [ 1 , 2 , 11 , 14 , 20 , 21 , 23 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. However, most of them showed signs of recurrence.…”

Section: Discussionmentioning

confidence: 99%

White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report

Qiao

Liu

Bai

et al. 2022

Genes

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White sponge nevus (WSN) is a rare autosomal dominant disease with a family history, often caused by mutations of the keratin 4 (K4) and keratin 13 (K13) genes in patients. It is characterized by frequently occurred white corrugated folds in the bilateral buccal mucosa with soft texture. On histopathological examination, hyperkeratosis of epithelial cells, edema, and vacuolar changes in the spinous cells are observed in the lesions, despite a normal layer of basal cells. WSN should be differentiated from other oral white spot diseases, mainly oral lichen planus, oral candidiasis, oral white edema, and Heck’s disease, to reduce misdiagnosis and unnecessary treatment. At present, there is no specific treatment method. The purpose of this study was to report the clinical data of four WSN patients of the same family with the K4 gene mutation. The occurrence of WSN in a pair of monozygotic twins with very similar clinical presentations was identified for the first time. The gene sequencing results showed that there was a heterozygous deletion (C. 438_440delCAA) in exon 1 of the K4 gene, resulting in an aspartic acid loss in both the proband and his father. Finally, the etiology, pathogenesis, pathological manifestations, clinical manifestations, diagnosis, differential diagnosis, and related treatment methods are discussed to provide a reference for clinical treatment of the disease.

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Section: Discussionmentioning

confidence: 99%

White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report

Qiao

Liu

Bai

et al. 2022

Genes

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“…WSN does not usually require management except patient education and reassurance. No standard protocol has been established, but treatment often includes improving the mucosal aesthetics and texture [ 15 ]. Partial remissions have been recorded with the use of tetracycline mouth rinses and long-term, low-dose systemic antibiotic therapy [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Familial White Sponge Nevus in Saudi Arabia

Akeel¹,

AlFarabi²,

Binsaad³

et al. 2022

Cureus

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White sponge nevus (WSN) is an uncommon, benign, autosomal dominant disorder that usually appears at birth or in early childhood. It affects males and females equally and is caused by germ line mutations of the keratin genes leading to keratin instability and tonofilament aggregation. The condition causes painless, white, thickened, corrugated plaques to form on the oral mucosa, especially bilaterally on the buccal mucosa. Extra-orally, it occurs most often in the vaginal mucosa, as well as in the nasal and esophageal mucosa. In this report, we describe the case of a healthy 32-year-old Saudi male in Jizan in southern Saudi Arabia whose general dentist referred him to the oral medicine clinic at King Abdulaziz University Hospital, where he was diagnosed with white sponge nevus. The patient reported no medical problems and was a cigarette smoker for more than 10 years. An oral examination revealed white lesions affecting the buccal mucosa bilaterally and the labial mucosa. A biopsy of the buccal mucosa confirmed the diagnosis of white sponge nevus. Laser therapy was suggested for the aesthetic treatment of the lesions. Better awareness of this hereditary condition among dental professionals can help improve timely diagnoses early in life and thus avoid unnecessary or inadequate treatment for this benign condition.

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“…They also appear on the lips, alveolar ridges, and the floor of the mouth. 1 , 2 We herein present two affected members of a single family.…”

mentioning

confidence: 99%

“…Although it follows an autosomal dominant transmission pattern with incomplete penetrance, there have been reported cases without a family history. 1 , 2 , 3 The most frequently associated mutations are found in the genes encoding Cytokeratins 4 (KRT4) and 13 (KRT13). 4 , 5 Lesions usually appear during childhood or adolescence without a preference for either sex.…”

mentioning

confidence: 99%

Familiar white sponge nevus

Prada-García,

González-Morán,

Pérez-González

2024

Anais Brasileiros de Dermatologia

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Successful Treatment of White Sponge Nevus with Oral Doxycycline: A Case Report and Review of the Literature

Cited by 4 publications

References 8 publications

White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report

White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report

A Case Report on Familial White Sponge Nevus in Saudi Arabia

Familiar white sponge nevus

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