Successful Treatment of Vitiligo with Cold Atmospheric Plasma‒Activated Hydrogel

Zhai, Siyue; Xu, Mei; Li, Qiaosong; Guo, Kun; Chen, Hailan; Kong, Michael G.; Xia, Yumin

doi:10.1016/j.jid.2021.04.019

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…Following deionized water treatment with plasma, hydroxyethyl cellulose was mixed and treated once every other day in mice and patients. Vitiligo-related depigmentation, CXCL10, and dendritic cell and T cell (CD3+, CD8+) infiltration were reduced in mice, and the same results were obtained in a clinical trial involving 20 patients [34].…”

Section: Tissue Regenerationsupporting

confidence: 70%

Applications of Plasma-Activated Liquid in the Medical Field

Kim

2021

Biomedicines

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Much progress has been made since plasma was discovered in the early 1900s. The first form of plasma was thermal type, which was limited for medical use due to potential thermal damage on living cells. In the late 1900s, with the development of a nonthermal atmospheric plasma called cold plasma, profound clinical research began and ‘plasma medicine’ became a new area in the academic field. Plasma began to be used mainly for environmental problems, such as water purification and wastewater treatment, and subsequent research on plasma and liquid interaction led to the birth of ‘plasma-activated liquid’ (PAL). PAL is currently used in the fields of environment, food, agriculture, nanoparticle synthesis, analytical chemistry, and sterilization. In the medical field, PAL usage can be expanded for accessing places where direct application of plasma is difficult. In this review, recent studies with PAL will be introduced to inform researchers of the application plan and possibility of PAL in the medical field.

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Section: Tissue Regenerationsupporting

confidence: 70%

Applications of Plasma-Activated Liquid in the Medical Field

Kim

2021

Biomedicines

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“…Polymer materials are also a new research direction of antioxidant therapy. Recent work by Zhai et al ( Zhai et al, 2021 )showed that the Cold Atmospheric Plasma Activated Hydrogel was able to increase the expression of Nrf2 and decrease the activity of Nitric oxide synthase in a mouse model of vitiligo to increase the resistance of the cell to oxidative stress and immune overreaction. The method has been shown to work well in randomized controlled trials.…”

Section: Novel Therapeutic Approaches For Inflammatory Skin Diseasesmentioning

confidence: 99%

Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Oxidative stress plays a dominant role in inflammatory skin diseases. Emerging evidence has shown that the close interaction occurred between oxidative stress and the gut microbiome. Overall, in this review, we have summarized the impact of oxidative stress and gut microbiome during the progression and treatment for inflammatory skin diseases, the interactions between gut dysbiosis and redox imbalance, and discussed the potential possible role of oxidative stress in the gut-skin axis. In addition, we have also elucidated the promising gut microbiome/redox-targeted therapeutic strategies for inflammatory skin diseases.

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“…In conclusion, we thought that CAP could inhibit the excessive activation of immune cells, restrain the release of inflammatory chemokines, induce the expression of Nrf2 and weaken the inducible nitric oxide synthase activity to attenuate vitiligo (73). From these studies, we considered that CAP ameliorated vitiligo by producing the generation of follicular melanocytes, inhibiting the excessive infiltration of immune cells, restraining the release of inflammatory cytokines, and regulating the activity of oxidative or anti-oxidative systems (Figure 6).…”

Section: Ros and Rns Attenuated Ncisds Via Keratinocytes' Apoptosis I...mentioning

confidence: 90%

Cold Atmospheric Plasma Ameliorates Skin Diseases Involving Reactive Oxygen/Nitrogen Species-Mediated Functions

2022

Self Cite

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Skin diseases are mainly divided into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The pathogenesis might include microbial infections, autoimmune responses, aberrant cellular proliferation or differentiation, and the overproduction of inflammatory factors. The traditional therapies for skin diseases, such as oral or topical drugs, have still been unsatisfactory, partly due to systematic side effects and reappearance. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has demonstrated its safe and effective functions in dermatology. With its generation of reactive oxygen species and reactive nitrogen species, CAP exhibits significant efficacies in inhibiting bacterial, viral, and fungal infections, facilitating wound healing, restraining the proliferation of cancers, and ameliorating psoriatic or vitiligous lesions. This review summarizes recent advances in CAP therapies for various skin diseases and implicates future strategies for increasing effectiveness or broadening clinical indications.

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Successful Treatment of Vitiligo with Cold Atmospheric Plasma‒Activated Hydrogel

Cited by 21 publications

References 37 publications

Applications of Plasma-Activated Liquid in the Medical Field

Applications of Plasma-Activated Liquid in the Medical Field

Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases

Cold Atmospheric Plasma Ameliorates Skin Diseases Involving Reactive Oxygen/Nitrogen Species-Mediated Functions

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