1996
DOI: 10.1046/j.1365-2141.1996.d01-1707.x
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Successful treatment of virus‐associated haemophagocytic syndrome in adults by cyclosporin A supported by granulocyte colony‐stimulating factor

Abstract: Two young adult patients with typical virus-associated haemophagocytic syndrome (VAHS) were treated with cyclosporin A and granulocyte colony-stimulating factor (G-CSF). Clinical symptoms such as high fever and malaise disappeared rapidly with concurrent haematological improvement in both patients. The serum levels of interleukin-6 (IL-6), soluble IL-2 receptor, tumour necrosis factor and macrophage-CSF were all elevated before treatment but that of G-CSF was not. The dramatic effect of cyclosporin A observed … Show more

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Cited by 49 publications
(28 citation statements)
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(6 reference statements)
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“…Recent reports support the safety of Granulocyte-Colony Stimulating Factor (G-CSF) in patients with VAHS and severe neutropenia 3,23,44,45 . M-CSF is described as a trigger to the macrophage activation, increasing hemophagocytosis and worsening cytopenia 11,12,35 .…”
mentioning
confidence: 99%
“…Recent reports support the safety of Granulocyte-Colony Stimulating Factor (G-CSF) in patients with VAHS and severe neutropenia 3,23,44,45 . M-CSF is described as a trigger to the macrophage activation, increasing hemophagocytosis and worsening cytopenia 11,12,35 .…”
mentioning
confidence: 99%
“…Haemophagocytic syndrome seems to be related to T-cell deregulation and a broad spectrum of inflammatory cytokines has been reported to be increased in patient sera, including M-CSF (Tsuda & Shirono, 1995). Tsuda & Shirono (1996) emphasized in their report that serum G-CSF levels were rarely elevated in haemophagocytic syndrome. Although G-CSF does not appear to be involved in initiation of this syndrome, systemic administration of supraphysiological doses of this cytokine could maintain or even increase macrophage activation.…”
Section: Department Of Medicinementioning
confidence: 99%
“…In the report of Tsuda & Shirono (1996), G-CSF administration was discontinued after WBC recovery which occurred promptly after the onset of treatment. However, G-CSF doses were relatively low (100 mg/d for a 21-year-old patient).…”
Section: Department Of Medicinementioning
confidence: 99%
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