Successful treatment of verrucous epidermal nevus with fractional micro-plasma radio-frequency technology and photodynamic therapy

Abstract

Verrucous epidermal nevus (VEN) is a skin disorder that commonly presents at birth; it is characterized by skin-colored to brown verrucous papules in a linear distribution following Blaschko's lines. Even though it is extremely rare, VEN has been associated with malignant transformation. VEN has been treated by different treatment modalities with varying and frustrating results. We introduce a new type of treatment. The fractional micro-plasma radio-frequency (RF) technology, which uses unipolar RF technology to provoke plasma spars, creating multiple controlled micro-perforations on the skin. Photodynamic therapy (PDT) is a type of technology for disease diagnosis and treatment, in which a photosensitizer gathers within the nidus and kills the diseased cells. In this report, we present a case of VEN that was successfully treated with fractional micro-plasma RF technology and PDT without side effects or complications; a follow-up was conducted after 24 months and no signs of recurrence were observed.

Safety and effectiveness of 5‐aminolevulinic acid photodynamic therapy combined with fractional micro‐plasma radio‐frequency treatment for verrucous epidermal nevus: A retrospective study with long‐term follow‐up

“…[8][9][10] We reported a case of VEN successfully treated with ALA-PDT previously. 11 In the study here, we made a retrospective analysis of ALA-PDT in treating VEN and confirmed the effectiveness and safety.…”

“…We have also reported the administration of ALA-PDT in treating VEN. 11 It is well known that the penetration of photosensitizers in lesions is less than 1 mm. 18 Considering that the thickened lesions of VEN were not conducive to absorbing photosensitizers, we pretreated lesions with fractional micro-plasma RF before performing ALA-PDT.…”

Evaluation of Plasma-Assisted Noninvasive Surgery (PANIS) as a New Technique for Sublimating Large Benign Conjunctival Nevus with Amniotic Membrane Transplantation (AMT); A Clinical Case Report

“…Recently, plasma radiofrequency ablation has been used to remove various nevi in different parts of the body such as skin and around the eye and its safety has been discovered (33,34). Based on our previous studies on the PANIS method and its e cacy, it has shown that this method can be a minimally invasive technique for various ocular surface disorders (10)(11)(12)(13)(14)(15).…”

Evaluation of Plasma-Assisted Noninvasive Surgery (PANIS) as a New Technique for Sublimating Large Benign Conjunctival Nevus with Amniotic Membrane Transplantation (AMT); A Clinical Case Report

“…Recently, plasma radiofrequency ablation has been used to remove various nevi in different parts of the body such as skin and around the eye and its safety has been discovered (33,34). Based on our previous studies on the PANIS method and its e cacy, it has shown that this method can be a minimally invasive technique for various ocular surface disorders (10)(11)(12)(13)(14)(15).…”