Successful treatment of unresectable inflammatory pseudotumor of the lung with COX‐2 inhibitor

Chan, P. W. K.; Omar, Khairul Zaman; Ramanujam, T. M.

doi:10.1002/ppul.10308

Cited by 22 publications

(15 citation statements)

References 9 publications

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“…In both cases, NSAID therapy was discontinued at the time of achieving CR and the patients subsequently remained in remission. The case report of Chan et al (13) is the only case of NSAID therapy of pulmonary IMT other than our own case. The reported patient had an unresectable right lung mass, was febrile and toxic-appearing, with laboratory results indicative of acute inflammation with thrombocytosis, elevated ESR and elevated CRP.…”

Section: Case Reportmentioning

confidence: 43%

Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of the literature

Chavez

Hoffman

2013

Oncology Letters

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We report a case in which a 52-year-old female developed a multifocal inflammatory myofibroblastic tumor (IMT) of the lung. The tumor did not overexpress the anaplastic lymphoma kinase (ALK) protein, indicating a lack of ALK rearrangement. The patient required two wedge resections in 15 months due to recurrent disease. Recurrence after the second surgery was treated with corticosteroids, which only led to a transient response (6 months). Introduction of celecoxib, a cyclooxygenase-2 inhibitor, induced a complete remission in the patient. Maintenance on celecoxib further led to a progression-free survival of 34 months. A literature review retrieved a total of eight case reports, comprising ten patients, of IMT of various anatomical sites successfully treated with non-steroidal anti-inflammatory agent (NSAID) therapy. Nine of the ten patients achieved durable complete remission. Remission occurred rapidly and persisted even after termination of NSAID therapy. Although such a successful outcome may only be achieved rarely, a trial of an NSAID should be considered in any patient in whom complete resection is not an option. Our case also demonstrates that NSAID therapy may be successful in a non-ALK rearranged tumor in which ALK inhibition is not an option.

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Section: Case Reportmentioning

confidence: 43%

Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of the literature

Chavez

Hoffman

2013

Oncology Letters

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“…However, IMT is considered to be a neoplasm of intermediate biological potential, which may recur and metastasize, although infrequently (1–4). In unresectable cases, radiotherapy and chemotherapy, including steroids and NSAIDs, were applied (7–14,17,18). Indeed, several clinical reports indicated the usefulness of steroids and NSAIDs (11,13,17,18), although both failed to shrink the tumor in the present case.…”

Section: Discussionmentioning

confidence: 99%

“…In unresectable cases, radiotherapy and chemotherapy, including steroids and NSAIDs, were applied (7–14,17,18). Indeed, several clinical reports indicated the usefulness of steroids and NSAIDs (11,13,17,18), although both failed to shrink the tumor in the present case. Various cytotoxic agents or regimens, including MTX, VNB, vincristine, cyclophosphamide, doxorubicin, 5-fluorouracil, cisplatin, carboplatin, paclitaxel, ifosfamide and etoposide, have been used.…”

Section: Discussionmentioning

confidence: 99%

Relapsed and unresectable inflammatory myofibroblastic tumor responded to chemotherapy: A case report and review of the literature

Maruyama

Fukushima

Gomi

et al. 2017

Molecular and Clinical Oncology

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A 63-year-old female patient who had undergone cholecystectomy for inflammatory myofibroblastic tumor (IMT) in the gallbladder was referred to our hospital. The patient's disease relapsed, involving the pancreas, and was diagnosed as inoperable IMT 13 months after the cholecystectomy. The patient failed to respond to steroid and non-steroidal anti-inflammatory drug therapy, but subsequently exhibited a good response to vinorelbine and methotrexate combination chemotherapy. Little information is currently available on the efficacy of chemotherapy for adult-onset IMT. The present case suggests that chemotherapy with vinorelbine and methotrexate is a viable therapeutic option for adult patients with unresectable IMT.

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“…There are also reports of disease control with thalidomide [26] and infliximab [16]. Corticosteroids [27] and non-steroidal anti-inflammatory drugs [28] have been reported to induce disease regression.…”

Section: Discussionmentioning

confidence: 99%

A Rare Cause of an Endobronchial Tumour in Children: The Role of Interventional Bronchoscopy in the Diagnosis and Treatment of Tumours while Preserving Anatomy and Lung Function

Breen

Dubus²,

Chetaille³

et al. 2007

Respiration

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An 11-year-old girl was referred to our institution with complete obstruction of the left main stem bronchus by an endoluminal mass and was successfully treated by a combination of laser and mechanical debulking. Coring of the mass both allowed histological diagnosis (inflammatory myofibroblastic tumour) and definitive treatment with no recurrence after 3 years of follow-up. This case report emphasizes the major role of interventional bronchoscopy in the management of tumoural obstruction in children in whom benign conditions are frequent. Interventional bronchoscopy, which is minimally invasive when compared to surgery, in the vast majority of cases allows a precise diagnosis as it provides large samples of tissue removed during coring; in some cases it can be curative by itself and preserves lung parenchyma and function.

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Successful treatment of unresectable inflammatory pseudotumor of the lung with COX‐2 inhibitor

Cited by 22 publications

References 9 publications

Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of the literature

Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of the literature

Relapsed and unresectable inflammatory myofibroblastic tumor responded to chemotherapy: A case report and review of the literature

A Rare Cause of an Endobronchial Tumour in Children: The Role of Interventional Bronchoscopy in the Diagnosis and Treatment of Tumours while Preserving Anatomy and Lung Function

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