Successful treatment of three synchronous primary malignant tumours—reflection on surgical, pathological and oncological aspects and decision making

Ágoston, Emese Irma; Somorácz, Áron; Madaras, Lilla; Zaránd, Attila; Szentmártoni, Gyöngyvér; Orosz, Zsuzsanna; Dank, Magdolna; Baranyai, Zsolt

doi:10.1093/jscr/rjy041

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Therapy is generally based on a combination of several factors, such as patient age, clinicopathological features of the different tumors, biological and genomic expression profiles, life expectancy, and comorbid diseases. For MC-MPMNs, the treatment approach invariably involves sequential treatment of all tumors; however, for SC-MPMNs, individualized and unique treatment plans are generally developed after multidisciplinary discussions[ 44 ]. In this case, the patient presented with two successive asynchronous tumors of different histological origins, namely esophageal squamous epithelial carcinoma and DA.…”

Section: Discussionmentioning

confidence: 99%

Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature

Huang,

Ying,

Chen

et al. 2023

World J Gastrointest Surg

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BACKGROUND The prevalence of multiple primary malignant neoplasms (MPMNs) is increasing in parallel with the incidence of malignancies, the continual improvement of diagnostic models, and the extended life of patients with tumors, especially those of the digestive system. However, the co-existence of MPMNs and duodenal adenocarcinoma (DA) is rarely reported. In addition, there is a lack of comprehensive analysis of MPMNs regarding multi-omics and the tumor microenvironment (TME). CASE SUMMARY In this article, we report the case of a 56-year-old man who presented with a complaint of chest discomfort and abdominal distension. The patient was diagnosed with metachronous esophageal squamous cell carcinoma and DA in the Department of Oncology. He underwent radical resection and chemotherapy for the esophageal tumor, as well as chemotherapy combined with a programmed death-1 inhibitor for the duodenal tumor. The overall survival was 16.6 mo. Extensive evaluation of the multi-omics and microenvironment features of primary and metastatic tumors was conducted to: (1) Identify the reasons responsible for the poor prognosis and treatment resistance in this case; and (2) Offer novel diagnostic and therapeutic approaches for MPMNs. This case demonstrated that the development of a second malignancy may be independent of the location of the first tumor. Thus, tumor recurrence (including metastases) should be distinguished from the second primary for an accurate diagnosis of MPMNs. CONCLUSION Multi-omics characteristics and the TME may facilitate treatment selection, improve efficacy, and assist in the prediction of prognosis.

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Section: Discussionmentioning

confidence: 99%

Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature

Huang,

Ying,

Chen

et al. 2023

World J Gastrointest Surg

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“…If the generic association of breast cancer with urological tumors can be considered sporadic (11,12,16,31,44,61,76,86,95,96), the same cannot be said for bladder cancer (11,12,76,95).…”

Section: Breast Cancer and Gynecological Tumorsmentioning

confidence: 99%

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Luca

Frusone

Vergine

et al. 2019

In Vivo

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Multiple primary malignant neoplasms are multiple tumors with different pathogenetic origin. They may be synchronous or metachronous. The management of these conditions represents an interesting clinical scenario. A crucial aspect is the decision regarding which tumor to treat initially, and how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. We describe a case report of a female patient affected by primary synchronous tumors of the breast and pectoral skin, which raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature. Multiple primary malignant neoplasms (MPMNs), or multiple primary cancers, are defined as multiple tumors with different pathogenetic origin. The phenomenon of MPMN was first described by Billroth at the end of the 19th century (1) and since then several cases of double or even triple primary malignant neoplasms have been reported (1-3). Neoplasms can be synchronous or metachronous and may appear in a single organ or in multiple organs concurrently. According to Moertel (2), synchronous neoplasms are defined as those that occur within 6 months from the diagnosis of a previous malignant tumor, and metachronous neoplasms are defined as neoplasms that appear 6 months after the first diagnosed tumor (2). Despite many changes in the definition have been proposed, the diagnosis of MPMNs that is widely accepted is based on the criteria described by Warren and Gates (3). These criteria require that: (i) each tumor must have a clear picture and histological confirmation of malignancy; (ii) each tumor must be topographically distinct and separated by healthy mucosa (at least 2 cm of normal mucosa between two tumors of the same region); (iii) the lesions must be not metastases of each other (3). In this report, we describe our recent observation and treatment of a female patient affected by primary synchronous tumors of the breast and pectoral skin. This combination, to the best of our knowledge, has never been previously reported in the literature, and it raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature.

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Coincidental or Causal? Concurrence of Colorectal Carcinoma with Primary Breast Cancer

et al. 2021

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Successful treatment of three synchronous primary malignant tumours—reflection on surgical, pathological and oncological aspects and decision making

Cited by 4 publications

References 7 publications

Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature

Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma: A case report and review of literature

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Coincidental or Causal? Concurrence of Colorectal Carcinoma with Primary Breast Cancer

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