Successful Treatment of Synchronous Double Lung Primary Malignancies and Colon Cancer

Abstract

We report a rare case of multiple primary malignancies, double primary lung cancers, and synchronous colon cancer. Double primary lung cancers were synchronous with adenocarcinoma of the sigmoid (carcinoid tumor and adenocarcinoma). The patient subsequently underwent two surgeries, for lung and colon cancer, followed by four cycles of carboplatin and pemetrexed treatment for the lung adenocarcinoma, with an uneventful chemotherapy course. The patient has been followed up closely for the last 18 months via CT scans and tumor marker tests and has shown no evidence of recurrence or metastasis.

Acute myeloid leukemia post‑cytotoxic therapy following chemotherapy for thymoma: A case report

“…Therefore, in cases involving refractory co-existing malignancies, the continuation of definitive chemotherapy requires careful consideration. Key points that need to be considered with synchronous malignancies are patient fitness, the prognosis of each cancer, the chance of a cure, whether one tumor may be treated radically and the other sequentially, anticipated complications, obstructive symptoms and if other similar treatments may be used (12). In addition to the performance status being good in the case present herein, cytopenia caused by AML progressed; therefore, chemotherapy for AML was prioritized following a multi-disciplinary consultation board.…”

Multiple primary colon carcinomas with small cell neuroendocrine lung carcinoma: A case report and literature review

“…The prognosis of patients with synchronous primary colon cancers aligns with that of colon cancer alone. However, cases with synchronous lung cancer are associated with a higher risk of adverse outcomes and mortality [19] . Therefore, tumors with negative prognosis and higher risk should be treated rst when the patients are in a poor general condition and cannot undergo simultaneous radical excision.…”

“…To date, only 15 cases involving both pulmonary and colonic MPC, including this case, have been documented in previous literature (Table 1). Among these cases, primary lung cancer was identi ed initially in 7 patients [10,[14][15][16][17][18] , and the simultaneous diagnosis of lung cancer and colon cancer was identi ed in 10 of these cases within 6 months [10,14,15,17,[19][20][21][22] . The average age of the reported cases was 64.9 years, with 11 of 15 subjects being male.…”