Successful treatment of steroid-resistant Weber–Christian disease with biliary ductopenia using cyclosporin A

Long-Term Evolution of Cytophagic Histiocytic Panniculitis

“…As a consequence of their intervention, secretion of cytokines such as interleukin (IL)-2, IL-3, IL-4, tumor necrosis factor, and interferon-c (IFN-c) is inhibited. 31,32 Cyclosporine also interferes with the production of soluble IL-2 receptor, 30 which is detected in patients with hemophagocytic syndrome. 27 With regard to this, Iwasaki and colleagues reported the successful treatment of CHP with cyclosporine with normalization of serum interferon (IFN-c) and soluble IL-2 receptor.…”

Weber–Christian disease associated with granulomatous mastitis: a variant type of Weber–Christian disease?

“…Corticosteroid therapy is beneficial for both and should be the initial choice of treatment [1,12,14,15]. Our patient showed a good response to steroid therapy alone, but those resistant to steroids may require immunosuppressant drugs, including methotrexate, cyclosporine A or azathioprine [14,15].…”

Lobular panniculitis with small vessel vasculitis associated with ulcerative colitis

“…Unusual manifestations of WCD can include epididymal, pancreatic, splenic, and pulmonary sterile abscesses with focal infiltrates of fat tissue. Although an association between WCD and vasculitis has been reported, the eponym of Weber-Christian panniculitis should be abandoned because a more specific diagnosis may be rendered in most cases [7][8][9]. In our case, a final descriptive diagnosis of lobular panniculitis involving subcutaneous and visceral fat, with sterile neutrophilic infiltration and small vessel vasculitis was made.…”