Successful Treatment of Sepsis Caused by Staphylococcus lugdunensis in an Adult with 22q11.2 Deletion Syndrome

Shoji, Hirokazu; Murakami, Kazutoshi; Mizushima, Takaaki; Ohmori, Kazuyoshi; Fujita, Seiko; Hanayama, Yoshihisa; Kanamori, Tatsuya; Yokota, Ryo; Ebara, Hirotaka; Kusano, Nobuchika; Kudo, Chieko; Yamaguchi, Tomoko; Akagi, Teiji; Koide, Naoki

doi:10.2169/internalmedicine.51.6257

Cited by 5 publications

(1 citation statement)

References 25 publications

(24 reference statements)

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“…SL and Staphylococcus aureus (SA) are known for having a higher pathogenicity than other CoNS (1). Previous reports have demonstrated that SL can cause infective endocarditis (IE), catheter-related bloodstream infections, and skin and soft tissue infections (2-4); however, there have been only 4 reports on SL infections in Japan (5)(6)(7)(8). Three additional reports have described the detection rates of SL in specimens of unknown clinical status (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Multicenter Study of the Clinical Presentation of <i>Staphylococcus lugdunensis</i> Bacteremia in Japan

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Multicenter Study of the Clinical Presentation of <i>Staphylococcus lugdunensis</i> Bacteremia in Japan

et al. 2017

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The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome

et al. 2017

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22q11.2 microdeletion is the most common microdeletion in humans. The purpose of this study was to evaluate postoperative outcome in children with 22q11.2 microdeletion who had undergone complete surgical correction of a congenital heart defect. The study included 34 patients who underwent complete correction of conotruncal heart defects. Of these, 17 patients diagnosed with 22q11.2 microdeletion represent the investigated group. Another 17 patients without 22q11.2 microdeletion represent the control group. Investigated and control groups differ significantly for total length of stay in the hospital (average 37.35 and 14.12 days, respectively); length of postoperative stay in the intensive care unit (average 10.82 and 6.76 days, respectively); sepsis (eight and two patients, respectively); administration of antibiotics (15 and seven patients, respectively); duration of antibiotic therapy (average 17.65 and 14.59 days, respectively); occurrence of hypocalcemia (16 and 0 patients, respectively); and initiation of peroral nutrition during the postoperative course (average 10.29 and 3.88 days, respectively). No difference was found for duration of ventilatory support (average 6.12 and 4.24 days, respectively), administration of total parenteral nutrition, and postoperative mortality rate. The study results suggest that genotype of 22q11.2 microdeletion affects postoperative outcome after cardiac surgery. Possible targets for intervention in postoperative intensive care management are prevention and treatment of systemic infections, monitoring, and treatment of hypocalcemias, rational administration of antibiotics and careful planning of nutrition. Consequently, this could shorten patients' intensive care stay and overall duration of hospitalization.

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Immunological features of 22q11 deletion syndrome

Gennery

2013

Current Opinion in Pediatrics

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Newborn screening detects patients with athymic 22q11 deletion syndrome, but significant illness may complicate the picture, and dual diagnoses can confound treatment. Treatment options for these patients are becoming clearer. Hypoparathyroidism is associated with more severe infection, and immunoglobulin abnormalities are more common than previously recognized. Adult patients are symptomatic and management guidelines will help general physicians in managing these patients.

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Successful Treatment of Sepsis Caused by Staphylococcus lugdunensis in an Adult with 22q11.2 Deletion Syndrome

Cited by 5 publications

References 25 publications

Multicenter Study of the Clinical Presentation of <i>Staphylococcus lugdunensis</i> Bacteremia in Japan

Multicenter Study of the Clinical Presentation of <i>Staphylococcus lugdunensis</i> Bacteremia in Japan

The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome

Immunological features of 22q11 deletion syndrome

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