Abstract:Summary
What is known and objective
Determination of phenobarbital (PB) dosing during continuous haemodiafiltration (CHDF) requires evaluation of both the patient's own clearance and CHDF clearance.
Case description
Systemic clearance of PB in a 9‐year‐old female patient with Dravet syndrome, who was undergoing CHDF, was calculated by the Sawchuk‐Zaske method, and clearance by CHDF was calculated as the difference between PB levels in influx and efflux, adjusted for the blood purification conditions. Dosage ad… Show more
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