Successful treatment of <scp>D</scp>owling‐<scp>D</scp>egos disease using intense pulsed light

Gupta, Amrita; Huilgol, Shyamala C.

doi:10.1111/ajd.12232

Cited by 10 publications

(5 citation statements)

References 6 publications

(12 reference statements)

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“…Another study reported that using a fractional Er:YAG laser led to improvement of pigmentation in facial lesions of an Asian patient with DDD and was effective in reducing postoperative inflammation but could not produce the therapeutic results of an ablative approach . Recently, one case report showed that the pigmentation of lentigines in patients with DDD could be treated successfully using intense pulsed light, suggesting an alternative option for pigmented lesions in DDD …”

Section: The Spectrum Of Dowling‐degos Diseasementioning

confidence: 99%

Updated review of genetic reticulate pigmentary disorders

Zhang

Yao

2017

Br J Dermatol

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Reticulate pigmentary disorders are a group of disorders characterized by hyper- and/or hypopigmented macules with varying sizes and amounts of pigment. Some of the disorders are heritable, such as Dowling-Degos disease, dyschromatosis universalis hereditaria, dyschromatosis symmetrica hereditaria, reticulate acropigmentation of Kitamura and X-linked reticulate pigmentary disorder. Although each condition possesses unique phenotypic characteristics and the prognosis for each is somewhat different, there is a large degree of overlap between the disorders and therefore they are difficult to differentiate in the clinical setting. This updated review provides a clinical and molecular delineation of these genetic reticulate pigmentary disorders and aims to establish a concise diagnostic strategy to allow clinical dermatologists to make an accurate diagnosis, as well as to provide useful information for clinical and genetic counselling.

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Section: The Spectrum Of Dowling‐degos Diseasementioning

confidence: 99%

Updated review of genetic reticulate pigmentary disorders

Zhang

Yao

2017

Br J Dermatol

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“…Laser treatment appears to be promising. Both ablative and fractional Er:YAG laser [24,25] as well as high-energy flash lamps [26] have already been used successfully in patients with Dowling-Degos disease. These are, however, case reports.…”

Section: Discussionmentioning

confidence: 99%

Disseminated papular variant of Dowling‐Degos disease: Histopathological features in POGLUT1 mutation

Papadopoulou

Karsai

Böer‐Auer

2022

J Deutsche Derma Gesell

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Summary Dowling‐Degos disease is a rare benign genodermatosis. It is characterized by lentiginous hyperpigmentation and reddish‐brown papules and plaques. The flexor sides and intertrigines are often affected, but the clinical appearance may vary. Mutations in different genes are responsible for the clinical manifestation. While mutations in the keratin 5 (KRT5) gene favor a reticular distribution pattern, mutations in the POGLUT1 gene lead to a disseminated, papular clinical picture. Acantholytic variants of Dowling‐Degos disease have historically been referred to as Galli‐Galli disease, but our case study shows that the histopathological changes can vary even within a single patient. To date, no standardized therapy concept exists. The main focus is on keratolytic measures, with varying response. New therapeutic approaches using laser technology appear to be a promising treatment option.

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“…6 Laser treatments; especially CO2, Er:YAG, Nd:YAG have been reported in the literature with variable results. [10][11][12][13] Wenzel et al reported a case of DDD efficaciously treated using an ablative Er:YAG laser; however, their follow-up was only 2.5 years, and it was not clear whether the results were permanent. Adverse effects were not reported.…”

Section: Discussionmentioning

confidence: 99%

Dowling-Degos disease: report of a family with no response to laser treatments.

Navarrete‐Dechent

Dossi

Villagra

et al. 2018

Rev. chil. dermatol

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La enfermedad de Dowling-Degos, conocida tambien como ‘anomalia reticulada y pigmentada de las flexuaras’ es una rara genodermatosis autosomica domininante. Se caracteriza por la aparicion de hiperpigmentacion de configuracion reticulada, afectando principalmente los grandes pliegues como las axilas e ingle. Posteriormente, puede afectar otros pliegues como cuello, brazos, submamarios e intergluteos. Otras caracteristicas asociadas con las lesiones tipo comedones y los pits palmo-plantares.Presentamos el caso de una familia con enfermedad de Dowling-Degos sin respuesta al tratamiento con laser Nd:YAG y CO2. Se realiza una revisión de la literatura de los tratamientos disponibles.

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Successful treatment of Dowling‐Degos disease using intense pulsed light

Cited by 10 publications

References 6 publications

Updated review of genetic reticulate pigmentary disorders

Updated review of genetic reticulate pigmentary disorders

Disseminated papular variant of Dowling‐Degos disease: Histopathological features in POGLUT1 mutation

Dowling-Degos disease: report of a family with no response to laser treatments.

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