Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum

Abstract

Treatment with antirotavirus immunoglobulin of bovine colostral origin is effective in the management of children with acute rotavirus diarrhea.

The role of bovine colostrum on recovery time and length of hospital stay of acute diarrhea in infants and children: a double-blind randomized controlled trial

“…8,9 Our study shows that recovery time and length of hospital stay were shorther in the treatment group. Similar results were reported by Ylitalo et al 8 12 in Bangladesh in which oral hyperimune bovine colostrum was effective to accelerate the recovery time and the length of hospital stay for acute diarrhea caused by rotavirus in infants and children compared with control of 56 hours compared to 72 hours.…”

“…Bovine colostrums also contain growth factors that are synergically useful for the diarrhea recovery. [8][9][10] This study aimed to evaluate the role of bovine colostrums to the recovery time and the length of hospital stay in infants and children who suffered from acute diarrhea.…”

Production and Functional Properties of Dairy Products Containing Lactophorin and Lactadherin

“…α-LA and β-LG were present as major components in F3. As mentioned above, IgG was identified as a rotavirus inhibitor in bovine milk (Ebina et al, 1992;Sarker et al, 1998). Accordingly, to address the contribution of IgG to the anti-HRV activity of Dried MFRF, we attempted to separate IgG in each fraction from other components by using affinity chromatography on a HiTrap Protein G HP column (5 ml, GE Healthcare UK Ltd.).…”

“…It has been proposed that passive protection against HRV infection could be achieved by using immunoglobulin G (IgG) from the colostrum of cows hyper-immunized with rotavirus (Ebina et al, 1992;Sarker et al, 1998). Unfortunately, the clinical use of bovine colostrum from hyper-immunized cows has been limited because of difficulties in largescale production.…”

Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder

“…Based on the oral rehydration solution (ORS) recommen ded by World Health Organization (WHO) [10,11] , reduced osmolarity ORS [8] , addition of Lactobacillus GG to ORS [12,13] , and rice-based solution [14] have been used to treat this disease. Also, oral immunoglobulins was used as antiviral therapy [15,16] , and rotavirus candidate vaccines are developing [17] , in which a oral tetravalant, rhesus rotavirus-based, human reassortant vaccine has been licensed in USA [18] . To seek more effective and cheaper drugs to treat rotaviral diarrhea from Chinese medicinal herbs, we found that a Chinese traditional medical prescription named Qiwei Baizhu Powder (QWBZP) had been employed to treat acute diarrhea in infants and children for nearly one thousand years in Traditional Chinese Medicine (TCM).…”