Successful treatment of rhino-facial mucormycosis in a diabetic patient

Mtibaa, Latifa; Halwani, C.; Tbini, Makram; Boufares, Siwar; Souid, Hana; Sassi, Raja Ben; Gharsallah, Hédi; Mhamed, R. Ben; Akkari, K.; Jemli, Boutheina

doi:10.1016/j.mmcr.2020.01.003

Cited by 7 publications

(9 citation statements)

References 16 publications

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“…The duration of administration varies from 1 week to 3 years (average duration, 6 months). [ 10 ] In our case, no special symptoms of infection were observed after the surgical removal of mucormycosis; however, antifungal treatment was administered for a total of 3 months to prevent complications like fungal infection. Also, the reason that antifungal treatment was administrated is that 1-3-β-D-glucan tested after surgery showed a high value of 906.9 pg/mL.…”

Section: Discussionmentioning

confidence: 79%

“…Surgical excision and antifungal treatment are the standard treatments for primary cutaneous mucormycosis. [ 5 10 ] Surgical excision should proceed as perfectly as possible until healthy margins are obtained. In our case, preoperative computed tomography confirmed the presence of a 5.0 cm × 3.7 cm × 2.1 cm rim-enhanced fluid-density lesion and successful surgical excision of the isolated mucormycosis prevented invasion into the muscle and tissue around mucormycosis infection.…”

Section: Discussionmentioning

confidence: 99%

“…To date, only two antifungal agents, namely amphotericin B and posaconazole, are known to have reliable activity against mucormycosis. [ 10 ] Currently, no clear standard exists for the duration of the use of antifungal agents. Antifungal agents are mainly taken up to the resolution of symptoms of infection and substantial radiographical improvement.…”

Section: Discussionmentioning

confidence: 99%

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Primary Mucormycosis Infection in the Submandibular Area After Esthetic Lipolytic Injection in An Immunocompetent Patient

Bae

Kim

et al. 2022

Indian Journal of Dermatology

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As the popularity of injection lipolysis increases, several side effects of injection lipolysis have been reported. In this case, A 53-year-old woman visited our outpatient clinic with a new round-shaped protruding mass (size: 5.0 cm × 3.0 cm) in the submental area. The patient had received the injection lipolysis treatment before the visit. She had received injections in the submental area at 1-week intervals (i.e., 4, 5, and 6 weeks). We performed contrast-enhanced computed tomography of the neck for differential diagnosis and found a 5.0 cm × 3.7 cm × 2.1 cm rim-enhanced fluid-density lesion in the submental. Hence, surgical removal of the lesion was planned based on the diagnosis of unspecified complicated fluid collection. The removed mass was a 3.0 cm × 2.0 cm × 2.0 cm whitish fibrous tissue. Histological examination revealed mucormycosis infection. Although several side effects of lipolysis have been reported to date, mucormycosis infection in the submental area has not been reported before.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Mucormycosis Infection in the Submandibular Area After Esthetic Lipolytic Injection in An Immunocompetent Patient

Bae

Kim

et al. 2022

Indian Journal of Dermatology

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“…Thirty-six articles were obtained which fit our criteria [ Table 1 ]. [ 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 ] Data of 45 patients were noted. Male: female ratio found was 1.1 = 1.…”

Section: Literature Reviewmentioning

confidence: 99%

Mucormycosis of jaws – Literature review and current treatment protocols

Dewan

Patel

Pandya

et al. 2022

Natl J Maxillofac Surg

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Mucormycosis is a modern-day lifestyle disease that has burst into the health-care scenario. It is an opportunistic fungal infection that proliferates into the immunocompromised host by invasion of the fungus into the paranasal sinuses, thereby invading the palate, maxilla, and orbit. Left untreated it invades the cranial components such as cavernous sinus, skull base, and brain. Mucormycosis invades blood vessels, making these infections highly angioinvasive. We reviewed 45 cases of mucormycois of the head-and-neck region from 2010 to 2020 on the basis of electronic search peer-reviewed journals in Medline (PubMed) database. Presenting symptoms, risk factors, history of extraction, and treatment were tabulated and the data were analyzed. The mean age of patients was 53.8 years. 73.93% of patients had diabetes mellitus, 13.63% of patients had no immunocompromised state, and 8.74% of patients had other medical disorders. About 34.78% of cases had a history of extraction prior to manifestation of symptoms. Mucormycosis remains difficult to treat disease with a high mortality rate. At present, the triad of clinician's awareness, appropriate antifungal therapy, and aggressive surgical intervention represents treatment protocols against the disease.

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“…The introduction of its spores into the human body can be through inhalation, ingestion, and inoculation [9]. Commonly found agents which can cause infection in humans are Mucor species, Rhizopus species, Apophysomyces species, Rhizomucor species, Lichtheimia species, Cunninghamella bertholletiae, and Syncephalastrum species [15].…”

Section: Mucormycosismentioning

confidence: 99%

Risk of Mucormycosis in Diabetes Mellitus: A Systematic Review

Khanna¹,

Challa²,

Kabeil³

et al. 2021

Cureus

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Hyperglycemia or diabetes mellitus (DM) is a disorder of the endocrine system. In this condition, the body is insulin-deficient or resistant to insulin. Due to insulin deficiency or resistance, the body is unable to process sugar. The worldwide prevalence of diabetes mellitus is rising substantially.Hyperglycemia makes the immune system weak, which increases the risk of infection in a diabetic patient. Fungal infection is more common in DM. Mucormycosis is a rare fungal infection in a healthy individual, but in DM, it can cause severe complications and even be fatal if not treated adequately and timely. In our literature review, a total of 19 published articles from the PubMed database and Google Scholar were included. We combed the PubMed database and Google Scholar by using various inclusion and exclusion criteria. The result of the review study shows the increased risk of mucormycosis in a diabetic patient.

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Successful treatment of rhino-facial mucormycosis in a diabetic patient

Cited by 7 publications

References 16 publications

Primary Mucormycosis Infection in the Submandibular Area After Esthetic Lipolytic Injection in An Immunocompetent Patient

Primary Mucormycosis Infection in the Submandibular Area After Esthetic Lipolytic Injection in An Immunocompetent Patient

Mucormycosis of jaws – Literature review and current treatment protocols

Risk of Mucormycosis in Diabetes Mellitus: A Systematic Review

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