Successful treatment of refractory simple motor status epilepticus with lacosamide and levetiracetam

Abstract

Lacosamide has been reported to have been successfully used for non-convulsive status epilepticus after benzodiazepine failure, and convulsive status epilepticus after benzodiazepine and levetiracetam failure. We report a case of simple motor status epilepticus refractory to benzodiazepines and multiple anti-epileptic medications (AEDs) over 4 days. The addition of lacosamide in combination with existing levetiracetam aborted the continuous seizure with maintenance of seizure freedom through the most recent follow-up at 4 weeks.

Treatment of refractory simple partial status epilepticus by the addition of oral lacosamide in neurosurgical patients. Report of 3 cases

“…However, they supported the observation that the outcome at discharge seemed to depend considerably on the age of the patient and not on the therapeutic approach [3]. Chen et al presented a case of a 57-year-old male with refractory SPSE, already under levetiracetam, who became seizure-free after the initiation of lacosamide at an initial dosage of 50 mg bid and then gradually increased to 200 mg bid [4].…”

Single-Dose Oral Lacosamide in Refractory Simple Partial Status Epilepticus

“…Both LCS and its metabolites are excreted in urine. [3][4][5][6] Three received oral LCM, 4-6 and 1 was treated through a gastrocutaneous fistula. Cardiovascular events have also been reported.…”

“…1 Data are lacking regarding simple partial RSE outcomes. [3][4][5][6] We present 2 patients with simple partial RSE, treated with a single oral dose of LCM (300 mg). 1 Currently, no prospective clinical trial on lacosamide (LCM) use in SE, or in RSE, has been completed.…”

Combination drug therapy for the treatment of status epilepticus

“…formulations were approved in 2009. A few studies [92] and case reports [93,94] have reported on LCM as an add-on treatment for SE and RSE.…”