Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy

Yang, Hanwei; Xu, Xiu-Lian; Ran, Xin; Ran, Yuping

doi:10.1007/s13555-020-00384-w

Cited by 7 publications

(1 citation statement)

References 20 publications

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“…Candida tropicalis has been widely researched and found to reside on mucosal membranes rather than skin, with strong opportunistic pathogenicity and a high proportion of fluconazole-resistant properties [ 7 , 20 , 21 ]. The endometrium is also at risk of Candida tropicalis infection during pregnancy, and the skin is susceptible to hypoimmunity [ 22 , 23 ]. Although M. globose is the most common fungus on human skin, it normally concentrates on the face and upper trunk due to its lipophilicity, and the hands play a core role in the process of fungal metastasis [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of fungal communities on shared bicycles in Southwest China

et al. 2021

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Background The widespread use of shared bicycles has increased the demand and sanitary requirements for shared bicycles. Previous studies have identified potentially pathogenic bacteria on the surfaces of shared bicycles, but fungal communities have not been investigated. Methods We sampled shared-bicycle handles and saddles from five selected locations in a metropolis (Chengdu, China, n = 98) and used surrounding air deposition samples as controls (n = 12). Full-length ITS sequencing and multiple bioinformatic analyses were utilized to reveal fungal community structures and differences. Results Aspergillus was dominant on both the handles and saddles of shared bicycles, and Alternaria and Cladosporium were the most abundant families in the air samples. Significant differences in fungal community structures were found among the three groups. The handle samples contained higher abundances of Aureobasidium melanogenum and Filobasidium magnum than the saddle and air samples. The saddle samples had a higher abundance of Cladosporium tenuissimum than the other two sample types (P < 0·05). A higher abundance of fungal animal pathogens on shared-bicycle surfaces than in air by FUNGuild (P < 0·05). Moreover, the co-occurrence network of fungi on handles was more stable than that on saddles. Conclusion There were more potential pathogens, including Aspergillus pseudoglaucus, Aureobasidium melanogenum, Kazachstania pintolopesii, Filobasidium magnum, Candida tropicalis, and Malassezia globose were found on shared bicycles than in air, suggesting that hands should not contact mucous membrane after cycling, especially in susceptible individuals, and hygiene management of shared bicycles should be given more attention by relevant organizations worldwide.

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