Successful treatment of recalcitrant psoriasis with Indigo naturalis ointment

Lin, Yu‐Shan; Wong, Wen‐Rou; Pang, Jong Hwei S.

doi:10.1111/j.1365-2230.2006.02229.x

Cited by 12 publications

(13 citation statements)

References 4 publications

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“…We have been developing an alternative approach by topically applying the drug to skin lesions and thousands of psoriasis patients have been treated by this method since 2003 [5]. Results from randomized, observer-blind, vehicle controlled trials of an intra-patient comparison study demonstrated the safe and effective use of topical indigo naturalis ointment for the treatment of chronic plaque psoriasis [23].…”

Section: Discussionmentioning

confidence: 98%

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Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component

Lin

Leu

Yang

et al. 2009

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 98%

“…Alternatively, topical treatment may produce fewer adverse effects and transdermal absorption may be more efficient. In our previous clinical experience, indigo naturalis ointment can avoid adverse systemic effects while retaining anti-psoriatic efficacy and exhibiting significant histological improvement [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component

Lin

Leu

Yang

et al. 2009

Journal of Dermatological Science

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“…Furthermore, it costs much less in comparison with other topical agents. 6 We anticipate that indigo naturalis ointment can be an alternative or complementary therapy for psoriasis and believe it will be a great benefit to this large patient population.…”

Section: Commentmentioning

confidence: 99%

“…Primary observations showed that treatment with topical indigo naturalis ointment was beneficial for patients with recalcitrant psoriasis. 5,6 Then, an 8-week pilot study to evaluate the efficacy and safety of topically applied indigo naturalis on treating plaque-type psoriasis and analyze the histologic change in skin tissue was performed. Although the study had a limited number of patients, the results showed significant clinical improvement and marked skin biopsy improvement in proliferating, inflammatory, and differentiation markers.…”

mentioning

confidence: 99%

Clinical Assessment of Patients With Recalcitrant Psoriasis in a Randomized, Observer-Blind, Vehicle-Controlled Trial Using Indigo Naturalis

Lin¹,

Chang²,

Chang³

et al. 2008

Arch Dermatol

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Intervention:The patients applied either indigo naturalis ointment or vehicle ointment topically to each of 2 bilaterally symmetrical psoriatic plaque lesions for 12 weeks (depending on the date of enrollment in the study). Main Outcome Measures:The outcomes were assessed using the following criteria: the sum of ery-thema, scaling, and induration scores and the clearing percentage of the target plaque lesion assessed by 2 blinded observers.Results: Significant reductions in the sum of scaling, erythema, and induration scores (PϽ.001) (mean score, 6.3 after indigo naturalis treatment vs 12.8 in control subjects) and plaque area percentage (P Ͻ .001) (mean percentage, 38.5% after indigo naturalis treatment vs 90% in controls) were achieved with topical application of indigo naturalis ointment. Approximately 31 of 42 patients (74%) experienced clearance or near clearance of their psoriasis in the indigo ointment-treated lesion. Conclusion:Topical indigo naturalis ointment was a novel, safe, and effective therapy for plaque-type psoriasis.

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“…However, four patients reported transient itching after application of the ointment. In another study by Lin et al [14] about 95% reduction in the PASI score (Psoriasis Area Severity Index) and TBSA (total body surface area) after application of Indigo naturalis ointment were noted. They reported no allergic reactions or dermatitis in the studied psoriatic patients.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Traditional Chinese medicine herbs — are they safe for psoriatic patients?

Bartosińska

Pietrzak²,

Szepietowski³

et al. 2011

Folia Histochem Cytobiol.

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Abstract: Abstract: Abstract: Although traditional Chinese medicine (TCM) relies on remedies of natural origin, its use is not always safe as it can have not only beneficial but also deleterious effects. Psoriatic patients, disappointed by conventional treatment and unaware of the potential side effects of TCM preparations, are increasingly reaching for non-traditional therapeutic methods. This review presents brief characteristics of selected Chinese herbs self-prescribed by psoriatic patients. It is important that dermatologists should be able to recognize any potential hazards connected with current or previous taking of these herbs by their patients. (Folia Histochemica et Cytobiologica 2011, Vol. 49, No. 2, 201-205) Key words: Key words: Key words: Key words: Key words: traditional Chinese medicine, Chinese herbs, herbal medicine, psoriasis, adverse reaction Therefore, observing no immediate results, many patients become discouraged or frustrated and start looking for alternative means of treatment. Traditional Chinese medicine (TCM) is one option. However, the assumption that herbal preparations used in TCM, known as Chinese materia medica (CMM), are safe for human use (because of their natural origin), is a common misconception [1][2][3]. According to TCM proponents, this kind of treatment typically involves the application of herbs and vitamins as well as the use of a wide range of therapeutic methods, such as massages, acupuncture, diet and lifestyle modification [3].This paper attempts a short study of the characteristics of Chinese herbs available on the market and frequently found in herbal therapeutic mixtures. P P P P Pros and cons of TCM ros and cons of TCM ros and cons of TCM ros and cons of TCM ros and cons of TCM CMMs are believed to have a positive influence on various pathogenic mechanisms observed in pso-

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Successful treatment of recalcitrant psoriasis with Indigo naturalis ointment

Cited by 12 publications

References 4 publications

Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component

Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component

Clinical Assessment of Patients With Recalcitrant Psoriasis in a Randomized, Observer-Blind, Vehicle-Controlled Trial Using Indigo Naturalis

Traditional Chinese medicine herbs — are they safe for psoriatic patients?

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Successful treatment of recalcitrant psoriasis with Indigo naturalis ointment

Cited by 12 publications

References 4 publications

Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component

Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component

Clinical Assessment of Patients With Recalcitrant Psoriasis in a Randomized, Observer-Blind, Vehicle-Controlled Trial Using Indigo Naturalis

Traditional Chinese medicine herbs &#8212; are they safe for psoriatic patients?

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Traditional Chinese medicine herbs — are they safe for psoriatic patients?