Successful Treatment of Recalcitrant Primary Follicular Mucinosis with Indomethacin and Low-dose Intralesional Interferon Alpha

A case of idiopathic follicular mucinosis treated with bexarotene gel

“…In addition, topical and systemic psoralen plus ultraviolet A light (PUVA) therapy, topical nitrogen mustard, and radiation therapy have demonstrated some success . Isolated cases document the beneficial responses of pimecrolimus, dapsone, indomethacin, minocycline, isotretinoin, hydroxychloroquine, and interferons …”

“…7 Isolated cases document the beneficial responses of pimecrolimus, dapsone, indomethacin, minocycline, isotretinoin, hydroxychloroquine, and interferons. [8][9][10][11][12][13][14] This article reports the first case of successful treatment of idiopathic follicular mucinosis with topical bexarotene 1% gel. This patient presented with large areas of alopecia recalcitrant to topical clobetasol 0.05% ointment and narrow-band UVB.…”

Treatment of Primary Follicular Mucinosis with Imiquimod 5% Cream

“…Imiquimod, a topical imidazoquinoline, acts as a Toll‐like receptor 7 agonist, upregulating the synthesis of proinflammatory cytokines, such as interferons α and γ (3). There are no previous reports in the English literature of off‐label use of topical imiquimod 5% as a treatment for follicular mucinosis (5), although there are two reports of cases of PFM treated with intralesional interferons α and γ (6,7) in which complete clinical remission was achieved. Interferons have a variety of immunomodulatory properties, including a stimulating effect on the phagocytic and metabolic activity of macrophages (6).…”

Follicular mucinosis associated with pregnancy

“…This disease is divided into a primary and secondary type. The primary type of FM occurs when there is no underlying associated skin disease . The secondary type is associated with a number of inflammatory disorders and malignant conditions .…”