Successful treatment of pulmonary arteriovenous malformation and infantile hepatic hemangioendothelioma with alpha-interferon

We found there to be a limited evidence base for the treatment of infantile haemangiomas: a large number of interventions and outcomes have not been assessed in RCTs.Our key results indicate that in the management of IH in children, oral propranolol and topical timolol maleate are more beneficial than placebo in terms of clearance or other measures of resolution, or both, without an increase in harms. We found no evidence of a difference between oral propranolol and topical timolol maleate with regard to reducing haemangioma size, but we are uncertain if there is a difference in safety. Oral propranolol is currently the standard treatment for this condition, and our review has not found evidence to challenge this. However, these results are based on moderate- to very low-quality evidence.The included studies were limited by small sample sizes and risk of bias in some domains. Future trials should blind personnel and participants; describe trials thoroughly in publications; and recruit a sufficient number of children to deduce meaningful results. Future trials should assess patient-reported outcomes, as well as objective outcomes of benefit, and should report adverse events comprehensively. Propranolol and timolol maleate require further assessment in RCTs of all types of IH, including those considered problematic, as do other lesser-used interventions and new interventions. All treatments should be compared against propranolol and timolol maleate, as beta blockers are approved as standard care.

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Interventions for infantile haemangiomas of the skin

Novoa

Baselga

Beltrán

et al. 2018

Cochrane Database of Systematic Reviews

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Successful treatment of pulmonary arteriovenous malformation and infantile hepatic hemangioendothelioma with alpha-interferon

Abstract: ConclusionAs far as we know, our case with a combination of the two coronary artery anomalies is the first report in the literature, in which type 2 dual LAD artery and absent Cx has been described in the same patient.

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Interventions for infantile haemangiomas of the skin

Interventions for infantile haemangiomas of the skin

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