Successful Treatment of Pathological Jealousy with Pimozide

Pathological Jealousy Treated With Pimozide

“…Successful treatment of pathological jealousy by pimozide was first reported by Dorian [9]. Since then three other reports [3,7,8] have been published and in all of them the response to pimozide was excel› lent, as was observed in our patient. In addi› tion, there is evidence that erotomania and.…”

“…It can occur in association with chronic alcoholism, organic brain disor› der, schizophrenia and affective disorder [1] or it may present as the only delusion in delusional disorder [2]. The treatment of pathological jealousy is difficult [3][4][5][6][7][8]. A case of pathological jealousy who did not respond to phenothiazines, antidepressants, electro› convulsive therapy and psychotherapy but responded dramatically to pimozide is re› ported.…”

Pharmacotherapy of delusional disorders in the context of offending and the potential for compulsory treatment

“…After six weeks on between 2 and 12 mg of pimozide, a dopamine antagonist that is rarely used now in routine clinical practice, no significant changes were found in symptoms or functioning, or on the scale used to measure five dimensions of delusional experience. The lack of benefit was in contrast to earlier case studies and non-controlled trials, which suggested that pimozide might be effective in treatment of delusional disorder, erotomanic type (Munro, O'Brien, & Roll, 1985), delusional disorder, jealous type (Byrne & Yatham, 1989;Pollock, 1982), delusional disorder, persecutory type (Ungvari & Hollokoi, 1993), and delusional disorder, somatic type (Riding & Munro, 1975). …”

Normal Pressure Hydrocephalus Presenting as Othello Syndrome: Case Presentation and Review of the Literature

“…With respect to delusions specifically, a retrospective chart review showed that both first-and second-generation antipsychotic medications were efficacious in restoring competency in the majority of incompetent criminal defendants diagnosed with delusional disorder (45). The neuroleptic pimozide has historically been recommended for the management of delusional jealousy, although no definitive trial-based data exist to guide its preferential use in the context of NPH or even of delusional disorder over other available atypical antipsychotics (46)(47)(48). Some clinicians may opt to treat delusional disorder with a trial of primozide, in lieu of other antipsychotics, based on the patient's tolerability of the medication's distinctive side effect profile.…”