“…However, PCs can recur after conservative treatment, and, although repeated aspirations may be performed, the effectiveness of this approach is variable [30,31]. Intracystic tetracycline injection may also be used in patients with a recurrence [32][33][34]. However, this has been associated with neck pain, neurotoxicity and recurrent nerve palsy due to leakage of the sclerosing agents through a disrupted thin cyst wall [35,36].…”
PCs are rare but should be included within the differential diagnosis of a neck lump. True PCs are non-functional. Pathological and immunohistochemical findings are suggestive of a branchial origin. Fine-needle aspiration may be curative and is diagnostic due to the characteristic appearance of the fluid and high PTH levels on assay.
“…However, PCs can recur after conservative treatment, and, although repeated aspirations may be performed, the effectiveness of this approach is variable [30,31]. Intracystic tetracycline injection may also be used in patients with a recurrence [32][33][34]. However, this has been associated with neck pain, neurotoxicity and recurrent nerve palsy due to leakage of the sclerosing agents through a disrupted thin cyst wall [35,36].…”
PCs are rare but should be included within the differential diagnosis of a neck lump. True PCs are non-functional. Pathological and immunohistochemical findings are suggestive of a branchial origin. Fine-needle aspiration may be curative and is diagnostic due to the characteristic appearance of the fluid and high PTH levels on assay.
“…The use of sclerosing agents entails the risk of fibrosis and recurrent laryngeal nerve palsy, especially when the inferior parathyroid is involved, because of its proximity to the inferior laryngeal nerve. 50,51 The choice of treatment should be tailored to each patient taking into account the size of the cyst and the presenting clinical findings.…”
BAcKGrOUND: Parathyroid cysts (Pc) are uncommon entities in routine clinical practice. The vast majority are nonfunctioning and are commonly present as asymptomatic nodular cervical lesions. Pc should be considered in the differential diagnosis of an asymptomatic neck mass. Large Pc can manifest with compressive symptoms of the surrounding tissues. OBJEcTIVE: The aim of this study is to describe nine new cases of Pc and review the current literature regarding the clinical presentation, the aetiopathology, the diagnostic procedures, as well as the therapeutic approaches for this relatively rare clinical entity. METHODs-PATIENTs: We present nine new patients (7 females and 2 males) diagnosed with Pc, which in three were ectopic. The diagnosis of Pc was based on the elevated levels of PTH in the cysts fluid. six of the patients had nonfunctioning parathyroid lesions, while the other three had functioning ones. Patients with functioning Pc had elevated serum calcium and PTH levels. Five out of nine of the cases had no symptoms, while two patients had compressive symptoms and the other two had signs and symptoms of hypercalcaemia. Needle aspiration (NA) was performed in five out of six patients with nonfunctioning Pc. surgery was the treatment in all three patients with functioning Pc. rEsULTs: remission after NA was achieved in four out of five patients with non-functioning Pc (follow-up time: 17.7±2.3 months). In two of them, two and three aspirations were needed. One patient with nonfunctioning Pc submitted to surgery with no previous NA. Patients with functioning Pc maintained remission after surgery (mean follow-up time: 22.1±2.9 months). In one of them, a second surgery was performed due to the co-existence of an ectopic parathyroid adenoma. cONcLUsIONs: The diagnosis of a Pc can be established by finding high levels of PTH in the fluid collected by the aspiration of the cyst. PTH and ca levels in the serum can differentiate functioning from nonfunctioning Pc. The treatment of HORMONES 2012, 11(4):410-418
Review
“…Surgical resection should be performed when the parathyroid cyst is functional, in recurrent cases or when obstructive symptoms are present. Other therapeutic options include percutaneous sclerosing agent infusion such as ethanol or tetracycline (34)(35)(36). Aspiration has been the main treatment modality in our cases.…”
Background: Parathyroid cyst is an infrequent and unsuspected disease. There are more than 300 hundred cases reported in the world literature, a few of them are from Latin America. The experience of our centers and a review of the cases are presented.Methods: Case report of a series of patients with parathyroid cyst from our institutions according to the CARE guidelines (Case Reports). A search of Medline, Embase, BIREME (Biblioteca Regional de Medicina)
LILACS (Literatura Latinoamericana y del Caribe en Ciencias de la Salud), Google Scholar and Scielo (ScientificElectronic Library on Line) databases and telephonic or email communications with other experts from LatinAmerica was performed .Results: Six patients with parathyroid cyst were found in our centers in Colombia. Most of them were managed with aspiration of the cyst. Two of them required surgery. Only one case was functional. Twelve reports from Latin America were found for a total of 18 cases in our region adding ours.
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