Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy

Chen, Hsin Ming; Chen, Yu; Tu, Ping; Yeh, Chien Yang; Tsai, Tsung‐Han; Chiang, Chun-Pin

doi:10.1002/lsm.20214

Cited by 101 publications

(129 citation statements)

References 29 publications

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“…The mean size score for 12 leukoplakia lesions before therapy was 1.82 ± 0.89 and 1.16 ± 0.98 after therapy, this difference was significant statistically (P < 0.001). The present study results obtained correlated with the study conducted by Kubler et al, 17 Kubler et al, 19 Tsai et al, 22 and Chen et al, 29 where in the study conducted by Kubler et al, 17 6 leukoplakia cases were treated by topical application of 5-ALA (20% cream) and irradiated with argon-pumped dye laser resulting complete response in 2 (33.33%) patients, partial response in 3 (50.0%) patients and no response in 1(16.66%) patient. In the other hand, our results are inconsistent with the results of the study conducted by Fan et al, 18 Kubler et al 19 and Franco.…”

Section: Discussionsupporting

confidence: 92%

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

et al. 2016

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Introduction: Oral premalignant lesions are conditions having high potential tendency for transformation into malignancy. The use of a conservative and effective treatment modality is one of the best strategies for cancer prevention. Photodynamic therapy (PDT) is a noninvasive method for topical and selective treatment of oral precancerous lesions. The present study was taken up to determine the efficacy of PDT in oral precancerous lesions. Methods: The study consisted 13 patients with 24 oral leukoplakia (OL) lesions and 8 with 20 oral lichen planus (OLP) lesions, divided into control and study groups. These lesions were affecting various intraoral sites, the buccal mucosa being the most common site followed by tongue and gingiva. The treatment regimen of PDT included 98% 5-aminolevulinic acid (5-ALA) which is topical applied and irradiated with light emitting diode (LED) of 420 nm wavelengths at several sessions. Results: In OL 16.6% of cases showed complete response, 66.6% partial response and 16.6% no response of the lesions to the treatment. In OLP 80% and 20% of the lesions showed partial and no response respectively. The differences with control groups for OL + OLP were found to be significant (P < 0.001). Conclusion: Based on the results of the present study, we can conclude that PDT appears to be a feasible alternative to conventional therapy for oral premalignant lesions.

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Section: Discussionsupporting

confidence: 92%

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

et al. 2016

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“…The fluorescence intensity in the malignant tissue reaches a maximum between 1 and 2 h after ALA application. 6,17,22,24 Numerous studies have shown that violet laser excitation induces both autofluorescence and ALA-induced fluorescence. 15,16,[18][19][20] The wavelength of the former is in the green-to-red range, whereas that of the latter falls mainly in the red band.…”

Section: Basis and Development Of The Image Processing Methodsmentioning

confidence: 99%

Comparative study of protoporphyrin IX fluorescence image enhancement methods to improve an optical imaging system for oral cancer detection

2011

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Abstract. Optoelectronics techniques to induce protoporphyrin IX fluorescence with topically applied 5-aminolevulinic acid on the oral mucosa have been developed to noninvasively detect oral cancer. Fluorescence imaging enables wide-area screening for oral premalignancy, but the lack of an adequate fluorescence enhancement method restricts the clinical imaging application of these techniques. This study aimed to develop a reliable fluorescence enhancement method to improve PpIX fluorescence imaging systems for oral cancer detection. Three contrast features, red-green-blue reflectance difference, R/B ratio, and R/G ratio, were developed first based on the optical properties of the fluorescence images. A comparative study was then carried out with one negative control and four biopsy confirmed clinical cases to validate the optimal image processing method for the detection of the distribution of malignancy. The results showed the superiority of the R/G ratio in terms of yielding a better contrast between normal and neoplastic tissue, and this method was less prone to errors in detection. Quantitative comparison with the clinical diagnoses in the four neoplastic cases showed that the regions of premalignancy obtained using the proposed method accorded with the expert's determination, suggesting the potential clinical application of this method for the detection of oral cancer. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…Pode ser dividida em indicações gerais (Quadro 11) e dermatológicas, e esta em oncológica e não oncológica. A TFD-ALA associada ao LED tem apresentado bons resultados no tratamento de lesões orais principalmente lesões de displasia da mucosa e carcinoma in situ 250,355 , carcinoma verrucoso extenso e de leucoplasia oral 356,357 .…”

Section: Indicações Da Terapia Fotodinâmicaunclassified

Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico

Ferolla¹

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Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy

Cited by 101 publications

References 29 publications

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

Comparative study of protoporphyrin IX fluorescence image enhancement methods to improve an optical imaging system for oral cancer detection

Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico

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